INFLUENCE OF A NEW ANTIULCER AGENT, AMMONIUM 7-OXOBICYCLO (2, 2, 1) HEPT-5-ENE-3-CARBAMOYL-2-CARBOXYLATE (KF-392) ON GASTRIC LESIONS AND GASTRIC MUCOSAL BARRIER IN RATS
スポンサーリンク
概要
- 論文の詳細を見る
Antiulcer effects of KF-392 were studied in several experimental gastric ulcer models in rats. It was found that KF-392 given orally at 1.0 to 5.0 mg/kg had a marked suppression on the developments of Shay ulcer as well as the aspirin-, stress-, and reserpine-induced gastric lesions. The influence of KF-392 on gastric mucosal barrier was also studied. A back diffusion of H<SUP>+</SUP> into the gastric mucosa and a fall of transmucosal potential difference were induced with KF-392 given orally at the above mentioned doses. KF-392 given s.c. at 5.0 mg/kg showed no inhibition on Shay ulcer and no induction of back diffusion of H<SUP>+</SUP> into the gastric mucosa.
- 社団法人 日本薬理学会の論文
著者
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Marumo Hirofuto
Pharmaceuticals Research Laboratory Kyowa Hakko Kogyo Co. Ltd.
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Kojima Tetsuo
Pharmaceuticals Research Laboratory Kyowa Hakko Kogyo Co. Ltd.
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TANAKA Hiroshi
Pharmaceuticals Research Laboratory, Kyowa Hakko Kogyo Co., Ltd.
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SUZUKI Yoshiro
Pharmaceutical Research Laboratories, Kyowa Hakko Kogyo Co., Ltd.
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MARUMO Hirofuto
Pharmaceutical Research Laboratories, Kyowa Hakko Kogyo Co., Ltd.
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MARUMO Hirofuto
Pharmaceutical Research Laboratories, Fuji Plant, Kyowa Hakko Kogyo Co., Ltd.
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TANAKA Hiroshi
Pharmaceutical Research Laboratories, Kyowa Hakko Kogyo Co., Ltd.
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KOJIMA Tetsuo
Pharmaceutical Research Laboratories, Fuji Plant, Kyowa Hakko Kogyo Co., Ltd.
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