Inhibitory Effect of KW-3635, a New Thromboxane A2-Receptor Antagonist, on Arterial Thrombosis in Guinea Pigs.
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概要
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The antithrombotic effects of the thromboxane (TX) A<SUB>2</SUB>-receptor antagonist and aspirin were determined using a photochemically-induced arterial thrombosis model in the femoral arteries of guinea pigs. KW-3635 (sodium (<I>E</I>)-11-[2-(5, 6-dimethyl-1-benzimidazolyl)ethylidene]-6, 11-dihydrodibenz[<I>b, e</I>]-oxepine-2-carboxylate monohydrate) and BM-13505, both of which are TXA<SUB>2</SUB>-receptor antagonists, and aspirin inhibited the thrombus formation at the doses that inhibited the ex vivo platelet aggregation induced by sodium arachidonate (100 μM) or collagen (3 μg/ml). These results support the notion that TXA<SUB>2</SUB> is an important mediator in the present model of arterial thrombogenesis.
- 公益社団法人 日本薬理学会の論文
著者
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HIGO Katsuya
Department of Pharmacology, Pharmaceutical Research Laboratories, Kyowa Hakko Kogyo Co., Ltd.
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Karasawa Akira
Deparment Of Pharmacology Pharmaceutical Research Laboratories Kyowa Hakko Kogyo Co. Ltd.
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