Neural Differentiation and Maturation in Metastatic Medulloblastoma : Case Report
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概要
- 論文の詳細を見る
A 6-year-old boy presented with a cerebellar medulloblastoma. Radical removal of the tumor and postoperative irradiation achieved complete remission. However, a metastatic tumor in the frontal lobe developed 2 years later. Radical removal and postoperative chemotherapy achieved partial remission, but he died of multiple intracranial and intraspinal dissemination of the tumor 2 years later. Comparison of the light microscopy, immunohistochemical staining, and electron microscopy findings from specimens of the tumors showed that the mainly undifferentiated primary tumor demonstrated both glial and neural differentiation, while the more mature metastatic tumor showed only neural differentiation. This suggests that differentiation and maturation of immature tumors such as medulloblastoma may proceed independently of metastatic potential.
- 日本脳神経外科学会の論文
- 1995-01-15
著者
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SATO Kiyoshi
Department of Microbiology, Sapporo Medical University School of Medicine
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ARAI Hajime
Department of Neurosurgery, Juntendo University School of Medicine
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Sato Kiyoshi
Department Of Microbiology Sapporo Medical University School Of Medicine
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Kadota Yoshiaki
Department Of Neurosurgery Juntendo University School Of Medicine:(present Address)department Of Neu
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Kadota Yoshiaki
Department Of Anesthesiology & Pain Medicine School Of Medicine Juntendo University
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Arai Hajime
Department Of Hematology And Oncology University Of Fukui
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Sato Kiyoshi
Department Of Biological And Chemical Engineering Gunma University
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