The Role of Bacterial Infection in the Pathogenesis of Inflammatory Bowel Disease
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概要
- 論文の詳細を見る
In the last decade, the dogma that no bacteria could grow in the acid milieu of the stomach has been destroyed by evidence that the infective agent, H. pylori, is responsible for gastric and duodenal disease. Studies on H. pylori infection suggest that some strains of intestinal bacteria may be responsible for intestinal ulceration and inflammation concomitant with inflammatory bowel diseases (IBD), i.e., ulcerative colitis and Crohn’s disease. Evidence for pathophysiological roles for certain strains of luminal bacteria result from a number of IBD animal models. Recent studies on innate immunity, including toll-like receptors and NOD isoforms, suggest that bacterial infections may contribute to intestinal inflammation in genetically susceptible hosts. This brief review focuses on the bacterial pathogenesis and the role of innate immunity in the etiology of IBD’s.
- 社団法人 日本内科学会の論文
- 2004-07-01
著者
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NOMURA Tetsuya
Department of Cardiovascular Medicine, Nantan General Hospital
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SATO Nobuhiro
Department of Critical Care Medicine, Iwate Medical University
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Sato Nobuhiro
Department Of Critical Care Medicine Iwate Medical University
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Nomura Tetsuya
Department Of Cardiology Maizuru Medical Center
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OHKUSA TOSHIFUMI
Department of Gastroenterology, Juntendo University, School of Medicine
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Nomura Tetsuya
Department Of Gastroenterology Juntendo University School Of Medicine
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Ohkusa Toshifumi
Department Of Gastroenterology Juntendo University School Of Medicine
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Ohkusa Toshifumi
Department Of Gastroenterology And Hepatology Kashiwa Hospital
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Sato Nobuhiro
Department of Cardio-angiology, Kitasato University School of Medicine
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