THE INHIBITORY EFFECT OF PAPAVERINE ON RESPIRATION-DEPENDENT CONTRACTURE OF GUINEA PIG TAENIA COLI IN HIGH-K MEDIUM. III. THE DIFFERENTIAL EFFECT OF PAPAVERINE AND ROTENONE ON DT DIAPHORASE

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概要

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• The differential effects of papaverine (Pap) and rotenone (Rot) were studied on the highly respiration-dependent contracture of guinea pig taenia coli in 40 mM potassium (40-K) medium, on isolated DT diaphorase activity and on mitochondrial respiration. The inhibition of guinea pig taenia coli to the 40-K induced tension by Rot (5 × 10<SUP>-7</SUP> M) was fully reversed by the addition of a water soluble vitamin K<SUB>3</SUB> (VK<SUB>3</SUB>) derivative or menadione sodium bisulfite (MSB). A low concentration (10<SUP>-7</SUP>-10<SUP>-6</SUP> M) of Pap which had no effect on the 40-K induced tension inhibited the VK<SUB>3</SUB> restored tension from the Rot suppression, corresponding to a Pap inhibition of the isolated DT diaphorase. Inhibition of the effective concentration of Pap to the 40-K induced tension development was never reversed by addition of VK<SUB>3</SUB> or MSB. In taenia coli, both MSB and VK<SUB>3</SUB> established a bypass of the Rot sensitive site on the mitochondrial respiratory chain by means of the DT diaphorase system. The difference in washoutefficacy between Pap and Rot on the inhibition of 40-K induced tension was ascribed to a difference in their mitochondrial binding properties.

• 社団法人 日本薬理学会の論文

著者

• Tsuda Shuji

  Laboratory Of Veterinary Public Health Department Of Veterinary Medicine Faculty Of Agriculture Iwat

• Fukami Jun-ichi

  Laboratory Of Biology Meiji College Of Pharmacy

• URAKAWA Norimoto

  Department of Veterinary Pharmacology, Faculty of Agriculture, University of Tokyo

• TSUDA Shuji

  Laboratory of Pharmacology, Toxicology Division, The Institute of Environmental Toxicokogy

• TSUDA Shuji

  Laboratory of Pharmacology, Toxicology Division, The Institute of Environmental Toxicology

• URAKAWA Norimoto

  Department of Veterinaly Pharmacology, Faculty of Agriculture, University of Tokyo

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