A comparative study on oxidative damage and distributions of perfluorooctane sulfonate (PFOS) in mice at different postnatal developmental stages
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概要
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Eeffects of perfluorooctane sulfonate (PFOS) on maleic dialdehyde (MDA) content, superoxide dismutase (SOD) activity and total antioxidation capability (T-AOC) were compared in mice at different postnatal developmental stages, and concentrations and distributions of PFOS in different tissues were measured simultaneously. The male and female mice at postnatal day (PD) 7, PD 14, PD 21, PD 28 and PD 35 were distributed randomly to dosage group (50mg/kg body weight) and control group (0mg/kg body weight). Mice were administered with PFOS by once subcutaneous injection. Subsequently, after 24hr, MDA content, SOD activity and T-AOC in brain and liver were analyzed. The PFOS concentrations in blood, brain and liver were determined by high-performance liquid chromatography negative electrospray tandem mass spectrometry (LC-MS). PFOS induced degression of the body weights of mice evidently and increase of relative weights of liver. Meanwhile, it depressed the SOD activity and T-AOC in brain and liver. The concentrations and distribution percentages of PFOS in blood, brain and liver of mice were significantly different at various postnatal developmental stages. Achieved results in this study indicate that younger mice pups were more sensitive to PFOS exposure. In addition, significant distinctions in concentrations and distribution percentages of PFOS in various tissues were demonstrated in this study. The gender difference observed was greater in the older mice. Thus it is worth giving attention especially to adverse effects of PFOS on foetus and children.
- 日本トキシコロジー学会の論文
- 2009-06-01
著者
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Sato Itaru
Department of Veterinary Medicine, Faculty of Agriculture, Iwate University
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Tsuda Shuji
Department of Veterinary Medicine, Faculty of Agriculture, Iwate University
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SATO Itaru
Laboratory of Veterinary Public Health, Department of Veterinary Medicine, Iwate University
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Saito Norimitsu
Research Institute for Environmental Sciences and Public Health of Iwate Prefecture
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Liu Wei
School of Environmental and Biological Science and Technology, Dalian University of Technology
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Liu Wei
School Of Environmental And Biological Science And Technology Dalian University Of Technology Key La
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Liu Wei
School Of Environmental And Biological Sci. And Technol. Dalian Univ. Of Technol. Key Lab. Of Indust
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Jin Yihe
School Of Environmental And Biological Science And Technology Dalian University Of Technology Key La
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Sato Itaru
Laboratory Of Veterinary Public Health Department Of Veterinary Medicine Faculty Of Agriculture Iwat
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Sato Itaru
Department Of Applied Veterinary Science The Doctoral Course Of The United Graduate School Of Veteri
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Tsuda Shuji
Laboratory Of Veterinary Public Health Department Of Veterinary Medicine Faculty Of Agriculture Iwat
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Tsuda Shuji
Department Of Veterinary Medicine Faculty Of Agriculture Iwate University
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Tsuda Shuji
Department Of Applied Veterinary Science The Doctoral Course Of The United Graduate School Of Veteri
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Jin Yihe
School Of Environmental And Biological Sci. And Technol. Dalian Univ. Of Technol. Key Lab. Of Indust
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Liu Li
Department Of Social Medicine School Of Public Health China Medical University
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Liu Li
Division of Hygienic Toxicology, School of Public Health, China Medical University
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Song Jinlan
School of Environmental and Biological Science and Technology, Dalian University of Technology, Key
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Yu Hongyao
Division of Hygienic Toxicology, School of Public Health, China Medical University
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Jin Yihe
Division of Hygienic Toxicology, School of Public Health, China Medical University
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Oami Kazunori
Graduate School of Life and Environmental Sciences, University of Tsukuba
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Tsuda S
Lab. Of Veterinary Public Health Dep. Of Veterinary Medicine Fac. Of Agriculture Iwate Univ.
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Yu Hongyao
Division Of Hygienic Toxicology School Of Public Health China Medical University
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Song Jinlan
School Of Environmental And Biological Science And Technology Dalian University Of Technology Key La
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Oami Kazunori
Graduate School Of Life And Environmental Sciences University Of Tsukuba
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TSUDA Shuji
Laboratory of Pharmacology, Toxicology Division, The Institute of Environmental Toxicokogy
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LIU Wei
School of Electronic, Information and Electrical Engineering, Shanghai Jiao Tong University
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Liu Li
Department of Social Medicine, School of Public Health, China Medical University
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Liu Wei
School of Aeronautics and Astronautics, Shanghai Jiao Tong University
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