Effects of perfluorooctane sulfonate (PFOS) on swimming behavior and membrane potential of paramecium caudatum
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概要
- 論文の詳細を見る
Persistent perfluorinated organic compounds such as perfluorooctane sulfonate (PFOS) and perfluorooctanoic acid (PFOA) were distributed widely in the global. PFOS (15 μM or higher) caused backward swimming of paramecia. The Triton-extracted paramecia, where the membrane was disrupted and the externally applied chemicals are freely accessible to the ciliary apparatus, showed forward swimming up to 0.1 μM Ca^<2+> in the medium and backward swimming at about 0.2 μM and higher. PFOS (0.1 mM) did not change the relationship between the swimming directions and free Ca^<2+> concentrations. Effects of various surfactants including PFOS and PFOA on the swimming direction of paramecia were compared with the hemolysis of mouse erythrocytes as an indicator of surfactant activities. The hemolysis did not correlate with their swimming behavior. PFOS caused triphasic membrane potential changes both in the wild-type paramecia and caudatum non-reversal (CNR) mutants, the latter is defective in voltage-gated Ca^<2+> channels. An action potential of the wild-type specimen was induced at lower current intensity when PFOS was present in the medium. Voltage-clamp study indicated that PFOS had no effect on the depolarization-induced Ca^<2+> influx responsible for the action potential. The membrane potential responses obtained were similar to those obtained by the application of some bitter substances such as quinine that activate chemoreceptors of paramecia. Since the CNR specimens did not exhibit PFOS-induced backward swimming at concentrations examined, the backward swimming is attributable to the influx of Ca^<2+> into the cilia through voltage-gated Ca^<2+> channels. The Ca^<2+> channels are most probably activated by the depolarizing receptor potentials resulted from the PFOS-induced activation of chemoreceptors.
- 日本トキシコロジー学会の論文
- 2008-05-01
著者
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Sato Itaru
Department of Veterinary Medicine, Faculty of Agriculture, Iwate University
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Tsuda Shuji
Department of Veterinary Medicine, Faculty of Agriculture, Iwate University
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SATO Itaru
Laboratory of Veterinary Public Health, Department of Veterinary Medicine, Iwate University
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Kawamoto Kosuke
Department of Veterinary Medicine, Faculty of Agriculture, Iwate University
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Saito Norimitsu
Research Institute for Environmental Sciences and Public Health of Iwate Prefecture
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Jin Yihe
School Of Environmental And Biological Science And Technology Dalian University Of Technology Key La
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Jin Yihe
Department Of Environmental Science And Technology Dalian University Of Technology
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Sato Itaru
Laboratory Of Veterinary Public Health Department Of Veterinary Medicine Faculty Of Agriculture Iwat
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Sato Itaru
Department Of Applied Veterinary Science The Doctoral Course Of The United Graduate School Of Veteri
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Tsuda Shuji
Laboratory Of Veterinary Public Health Department Of Veterinary Medicine Faculty Of Agriculture Iwat
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Tsuda Shuji
Department Of Veterinary Medicine Faculty Of Agriculture Iwate University
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Tsuda Shuji
Department Of Applied Veterinary Science The Doctoral Course Of The United Graduate School Of Veteri
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Jin Yihe
School Of Environmental And Biological Sci. And Technol. Dalian Univ. Of Technol. Key Lab. Of Indust
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Oami Kazunori
Graduate School of Life and Environmental Sciences, University of Tsukuba
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Tsuda S
Lab. Of Veterinary Public Health Dep. Of Veterinary Medicine Fac. Of Agriculture Iwate Univ.
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Oami Kazunori
Graduate School Of Life And Environmental Sciences University Of Tsukuba
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Kawamoto Kosuke
Laboratory of Veterinary Public Health, Department of Veterinary Medicine, Faculty of Agriculture, I
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Nishikawa Yasuo
Laboratory of Veterinary Public Health, Department of Veterinary Medicine, Faculty of Agriculture, I
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Nishikawa Yasuo
Department Of Veterinary Medicine Iwate University
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Kawamoto Kosuke
Department Of Veterinary Medicine Faculty Of Agriculture Iwate University
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TSUDA Shuji
Laboratory of Pharmacology, Toxicology Division, The Institute of Environmental Toxicokogy
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