Air purifiers that diffuse reactive oxygen species potentially cause DNA damage in the lung
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概要
- 論文の詳細を見る
Several appliance manufacturers have recently released new type air purifiers that can disinfect bacteria, fungi and viruses by diffusing reactive oxygen species (ROS) into the air. In this study, mice were exposed to the outlet air from each of 3 air purifiers from different manufacturers (A, B, C), and the lung was examined for DNA damage, lipid peroxidation and histopathology to confirm the safety of these air purifiers. Neither abnormal behavior during exposure nor gross abnormality at necropsy was observed. No histopathological changes were also observed in the lung. However, significant increase of DNA damage was detected by the comet assay in the lung immediately after the direct exposure for 48 hr to models A and B, and for 16 hr to model B. As for model B, DNA migration was also increased by 2 hr exposure in a 1 m3 plastic chamber but not by 48 hr exposure in a room (12.6 m3). Model C did not cause DNA damage. Lipid peroxidation and 8-hydroxy deoxyguanosine (8-OH-dG) was not increased under the conditions DNA damage was detected by the comet assay. The present results revealed that some models of air purifiers that diffuse ROS potentially cause DNA damage in the lung although the mechanism was left unsolved.
- 日本トキシコロジー学会の論文
- 2010-12-01
著者
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Sato Itaru
Department of Veterinary Medicine, Faculty of Agriculture, Iwate University
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Tsuda Shuji
Department of Veterinary Medicine, Faculty of Agriculture, Iwate University
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YOSHIDA Midori
Division of Pathology, National Institute of Health Sciences
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Yoshida Midori
National Institute of Health Sciences
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Kawamoto Kosuke
Department of Veterinary Medicine, Faculty of Agriculture, Iwate University
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Sato Itaru
Laboratory Of Veterinary Public Health Department Of Veterinary Medicine Faculty Of Agriculture Iwat
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Sato Itaru
Department Of Applied Veterinary Science The Doctoral Course Of The United Graduate School Of Veteri
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Sato Itaru
Department Of Applied Chemistry Faculty Of Science Science University Of Tokyo
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Tsuda Shuji
Department Of Veterinary Medicine Faculty Of Agriculture Iwate University
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Tsuda Shuji
Department Of Applied Veterinary Science The Doctoral Course Of The United Graduate School Of Veteri
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Yoshida Midori
Biological Safety Research Center National Institute Of Health Sciences
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Yoshida M
National Agricultural Research Center For Hokkaido Region
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Yoshida Midori
Division Of Pathology National Institute Of Health Sciences
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Yoshida M
Genomic Sciences Center Riken
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Yoshida Midori
Dept.pathol. Sasaki Inst.
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Tsuda S
Lab. Of Veterinary Public Health Dep. Of Veterinary Medicine Fac. Of Agriculture Iwate Univ.
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Matsuda Yuzuru
President Kyowa Hakko Kogyo Co. Ltd.
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Matsuda Yuzuru
Tokyo Research Laboratories Kyowa Hakko Kogyo Co. Ltd.
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Yoshida M
National Food Research Institute
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Yamasaki M
Biofrontier Laboratories Kyowa Hakko Kogyo Co. Ltd.
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Yoshida M
Kyowa Hakko Kogyo Co. Ltd. Tokyo Jpn
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Kawamoto Kosuke
Department Of Veterinary Medicine Faculty Of Agriculture Iwate University
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