Recent Advances in the Synthetic Studies of Nine-membered Enediyne Antitumor Antibiotics
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概要
- 論文の詳細を見る
The chromophores of the chromoprotein antibiotics C-1027, kedarcidin, and maduropeptin feature a unique nine-membered enediyne structure in the ansa-macrolide ring and show extremely potent cytotoxicity. Their complicated fused ring systems were recently synthesized and the total synthesis of (−)-maduropeptin chromophore was achieved, which thereby led to the revision of its stereochemical structure.
- 社団法人 有機合成化学協会の論文
著者
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Sato Itaru
Department of Veterinary Medicine, Faculty of Agriculture, Iwate University
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HIRAMA Masahiro
Department of Chemistry, Graduate School of Science, Tohoku University
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