Influence of gestation, regular bleeding and intermittent exposure on blood perfluorooctane sulfonate levels in mice : potential factors inducing sex difference and affectinq exposure evaluation
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概要
- 論文の詳細を見る
Higher blood levels of perfluorooctane sulfonate (PFOS) in males than the females have been observed in many human biomonitoring studies, which is not well explained yet. The effects of gestation and regular bleeding on blood PFOS level in mice were investigated to evaluate the potential factors that could result in the sex difference. The mice were exposed to PFOS via drinking water at a concentration of 50 μg/l. After 6 weeks of pre-exposure and the gestation period, the blood PFOS concentrations in the gestagenic mice were significantly lower than the control non-gestagenic mice with a ratio of 0.45. Significant lower blood PFOS concentrations in the male mice treated by regular artificial bleeding were observed compared with those from the control male. However, such difference was not observed for the females. The sex difference in the effect of regular artificial bleeding on the blood PFOS level may be caused by the different accumulation and elimination rate in the female and male mice. In addition, the effect of intermittent exposure to PFOS on blood level was evaluated. Each single exposure caused a significant increase in blood PFOS level in both females and males, suggesting the acute exposure to PFOS occurred before the blood sampling, e.g. exposure to PFOS-contaminated foods or drinks, would affect the biomonitoring data to some extent depending on the background blood level. Thus serial blood monitoring is required to obtain accurate body burden.
- 日本トキシコロジー学会の論文
- 2010-06-01
著者
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Sato Itaru
Department of Veterinary Medicine, Faculty of Agriculture, Iwate University
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Tsuda Shuji
Department of Veterinary Medicine, Faculty of Agriculture, Iwate University
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LIU Li
Department of Pharmacology, School of Pharmacy, Fourth Military Medical University
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SATO Itaru
Laboratory of Veterinary Public Health, Department of Veterinary Medicine, Iwate University
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Liu Wei
School of Environmental and Biological Science and Technology, Dalian University of Technology
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Jin Yihe
School of Environmental and Biological Science and Technology, Dalian University of Technology
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Liu Wei
School Of Environmental And Biological Science And Technology Dalian University Of Technology Key La
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Liu Wei
School Of Environmental And Biological Sci. And Technol. Dalian Univ. Of Technol. Key Lab. Of Indust
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Jin Yihe
School Of Environmental And Biological Science And Technology Dalian University Of Technology Key La
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Sato Itaru
Laboratory Of Veterinary Public Health Department Of Veterinary Medicine Faculty Of Agriculture Iwat
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Sato Itaru
Department Of Applied Veterinary Science The Doctoral Course Of The United Graduate School Of Veteri
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Tsuda Shuji
Laboratory Of Veterinary Public Health Department Of Veterinary Medicine Faculty Of Agriculture Iwat
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Tsuda Shuji
Department Of Veterinary Medicine Faculty Of Agriculture Iwate University
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Tsuda Shuji
Department Of Applied Veterinary Science The Doctoral Course Of The United Graduate School Of Veteri
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Li Xiao
School Of Pharmacy Shanghai Jiao Tong University
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Jin Yihe
School Of Environmental And Biological Sci. And Technol. Dalian Univ. Of Technol. Key Lab. Of Indust
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XU Lei
School of Environmental and Biological Science and Technology, Dalian University of Technology, Key
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Xu Lei
School Of Environmental And Biological Science And Technology Dalian University Of Technology Key La
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Liu Li
Department Of Social Medicine School Of Public Health China Medical University
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Tsuda S
Lab. Of Veterinary Public Health Dep. Of Veterinary Medicine Fac. Of Agriculture Iwate Univ.
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Liu Li
Department Of Pharmacology School Of Pharmacy Fourth Military Medical University
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Li Xiao
School Of Environmental And Biological Science And Technology Dalian University Of Technology Key La
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Li Xiao
School Of Agriculture And Biology Shanghai Jiaotong University
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Liu Li
Department Of Endocrinology And Metabolism Guangzhou Children Hospital
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TSUDA Shuji
Laboratory of Pharmacology, Toxicology Division, The Institute of Environmental Toxicokogy
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LIU Wei
School of Electronic, Information and Electrical Engineering, Shanghai Jiao Tong University
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Liu Li
Department of Social Medicine, School of Public Health, China Medical University
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Liu Wei
School of Aeronautics and Astronautics, Shanghai Jiao Tong University
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Liu Li
Department of Cardiology of Tangdu Hospital, Fourth Military Medical University
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