Activation of Peripheral Blood CD3+ T-lymphocytes in Patients With Atrial Fibrillation
スポンサーリンク
概要
- 論文の詳細を見る
Atrial fibrillation (AF) is a common disease with a poorly understood pathophysiological mechanism. Increasing evidence indicates that AF may be associated with immunologic inflammation responses, but it remains unclear whether activation of peripheral blood CD3+ T-lymphocytes plays a role in the pathogenesis of AF. The aim of this study was to evaluate this phenomenon. Fifty paroxysmal AF patients and 56 persistent AF patients who underwent successful electrical cardioversion were enrolled. The percentages of CD69 and human leukocyte antigen DR (HLA-DR) positive peripheral blood CD3+ T-lymphocytes, which indicate T-lymphocyte activation, were examined by flow cytometric analysis in the patients and 51 healthy controls. The patient groups had higher levels of CD69 and HLA-DR than the healthy controls. During the 3-month follow-up, 37 patients had recurrence of AF (recurrence group) and 50 patients remained in sinus (sinus group). The CD69 and HLA-DR levels in the sinus group were all significantly down-regulated at follow-up compared with before cardioversion. However, there were no statistically significant differences between the CD69 and HLA-DR levels in the recurrence group at follow-up and before cardioversion. Our findings suggest that activation of peripheral blood CD3+ T-lymphocytes was associated with AF, and might be a diagnostic or therapeutic marker.
著者
関連論文
- Nitric Oxide-Donating Genistein Prodrug : Design, Synthesis, and Bioactivity on MC3T3-E1 Cells
- EXPERIMENTAL STUDY FOR THE TOXICOLOGICAL EFFECTS OF SVATE-3 ON RAT LIVER : OBSERVATION BY LIGHT AND ELECTRON MICROSCOPE AND BY ENZYME HISTOCYTOCHEMISTRY
- Influence of gestation, regular bleeding and intermittent exposure on blood perfluorooctane sulfonate levels in mice : potential factors inducing sex difference and affectinq exposure evaluation
- Effect of Minor Au Addition on Glass-Forming Ability and Mechanical Properties of Pd-Cu-Au-Si-P Alloys
- 国際小児思春期糖尿病学会臨床診療ガイドライン2006-2008 : 第12章 小児・思春期糖尿病におけるシックデイの管理
- Formation of Bulk Pd-Cu-Si-P Glass with Good Mechanical Properties
- INCREASED EXPRESSION OF HEAT SHOCK PROTEIN (HSP)72 IN A HUMAN PROXIMAL TUBULAR CELL LINE (HK-2) WITH GENTAMICIN-INDUCED INJURY
- PC-407, a celecoxib derivative, inhibited the growth of colorectal tumor in vitro and in vivo
- Plasma free amino acids concentrations in galactosemia children
- Evaluating the risk of hypertension using an artificial neural network method in rural residents over the age of 35 years in a Chinese area
- Response of glial cells and activation of complement following motorneuron degeneration induced by toxic ricin
- Work-family Conflict and Burnout among Chinese Doctors : The Mediating Role of Psychological Capital
- Effect of triptolide on estradiol release from cultured rat granulosa cells
- Activation of Peripheral Blood CD3+ T-lymphocytes in Patients With Atrial Fibrillation
- IL-23R polymorphisms, HBV infection, and risk of hepatocellular carcinoma in a high-risk Chinese population