The Influence of Time, Sex and Geographic Factors on Levels of Perfluorooctane Sulfonate and Perfluorooctanoate in Human Serum over the Last 25 years
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概要
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Pertluorooctanesulfonate (PFOS) and perfluorooctanoate (PFOA) are important perfluorochemicals (PFCs) in various applications. Recently, it has been shown that these chemicals are widespread in the environment, wildlife and humans. But the kinds of factors that affect their levels in serum are unclear, and it is also not clear whether exposure to them is increasing or not. To investigate the impacts of time, geographical location and sex on the levels of these chemicals, we measured PFOS and PFOA concentrations in human sera samples collected both historically and recently in Miyagi, Akita and Kyoto Prefectures in Japan. The PFOS and PFOA levels in sera [Geometric Mean (Geometric Standard Deviation)] (μg/L) in 2003 ranged from 3.5 (2.9) in Miyagi to 28.1 (1.5) in Kyoto for PFOS and from 2.8 (1.5) to 12.4 (1.4) for PFOA. Historical samples collected from females demonstrated that PFOS and PFOA concentrations have increased by factors of 3 and 14, respectively, over the past 25 yr. There are large sex differences in PFOS and PFOA concentrations in serum at all locations. Furthermore, there are predominant regional differences for both PFOS and PFOA concentrations. In Kyoto the concentrations of PFOA in dwellers who had lived in the Kinki area for more than 2 yr were significantly higher than in people who had recently moved into the area, in both sexes. This finding suggests that there are sources of PFOA in the Kinki area that have raised the PFOA serum levels of its inhabitants. Further studies are needed to elucidate these sources in the Kinki area of Japan.
- 社団法人日本産業衛生学会の論文
著者
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Watanabe T
Miyagi University Of Education
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Koizumi A
Kyoto Univ. Kyoto Jpn
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Aoki Kunio
Department Of Health And Environmental Sciences Kyoto University Graduate School Of Medicine
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Koizumi Akio
秋田大学 衛生
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Saito Norimitsu
Research Institute for Environmental Sciences and Public Health of Iwate Prefecture
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WATANABE TAKAO
Miyagi University of Education
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Koizumi Akio
Department Of Hygiene Yamaguchi University School Of Medicinemedicine
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HARADA Kouji
Department of Health and Environmental Sciences, Graduate School of Medicine, Kyoto University
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INOUE Kayoko
Department of Health and Environmental Sciences, Graduate School of Medicine, Kyoto University
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Koizumi Akio
Department Of Health And Environmental Sciences Graduate School Of Medicine Kyoto University
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YOSHINAGA Takeo
Department of Health and Environmental Sciences Graduate School of Medicine, Kyoto University
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TANI YOSHIO
Seibo Jogakuin Junior College
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SASAKI Shiro
Hiraga General Hospital
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KAMIYAMA Shigetoshi
Medical Checkup Center, Miyagi Health Service Association
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Yoshinaga Takeo
Department Of Health And Environmental Sciences Graduate School Of Medicine Kyoto University
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Koizumi Akio
Department Of Health And Environmental Science School Of Public Health Kyoto University
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Harada Kouji
Department Of Health And Environmental Sciences Graduate School Of Medicine Kyoto University
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Harada Kouji
Department Of Computer Science & Electronic Engineering Tokuyama College Of Technology
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Inoue Kayoko
Department Of Health And Environmental Sciences Kyoto University Graduate School Of Medicine
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Kamiyama Shigetoshi
Medical Checkup Center Miyagi Health Service Association
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