The Effects of L-Glutamic Acid, Glutamate Agonists, Acetylcholine and Several Drugs on Excitatory Post-Synaptic Potentials at the Neuromuscular Junction of the Larval Mealworm, Tenebrio molitor LINNE (Coleoptera : Tenebrionidae)
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概要
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The effects of L-glutamic acid, quisqualic acid, L-aspartic acid, acetylcholine, curare, atropine, chlordimeform, nereistoxin, fenitrothion and fenitroxon on EPSP at the neuromuscular junction of the larval mealworm, Tenebrio molitor, were studied using a microelectrode technique. Applications of L-glutamic acid, quisqualic acid and L-aspartic acid suppressed 50% of EPSP at concentrations of 4.2×10^<-5> M, 2.3×10^<-5> M and 1.2×10^<-3> M and evoked a depolarization of muscle membrane with this EPSP reduction. However, acetylcholine at 2×10^<-3> M did not suppress EPSP but evoked a depolarization of the muscle membrane. Atropine, curare, nereistoxin and chlordimeform at a concentration of about 2×10^<-3> M suppressed 50% of EPSP. From a pharmacological aspect these results suggest that L-glutamic acid is an excitatory transmitter at the insect neuromuscular junction, because L-glutamic acid and quisqualic acid, its agonist, revealed the effect at forty and eight-fold lower concentrations than other drugs, respectively.
- 日本応用動物昆虫学会の論文
- 1984-05-25
著者
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Fukami Jun-ichi
Laboratory Of Biology Meiji College Of Pharmacy
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Usui Toako
Laboratory Of Insect Toxicology The Institute Of Physical And Chemical Research
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Usui Toako
Laboratory Of Insect Toxicolory The Institute Of Physical And Chemical Research
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Fukami Jun-ichi
Laboratory Of Insect Toxicology The Institute Of Physica And Chemical Research
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