Pharmacological Properties of Hindgut Visceral Muscle of the Cockroach, Periplaneta americana L.(Orthoptera:Blattidae) : I.The Effect of Glutamate Agonists, Glutamate Antagonists and Several Ion Channel Blockers

スポンサーリンク

概要

• 論文の詳細を見る

• Effects of agonists for glutamate receptors, L-glutamic acid, quisqualic acid, kainic acid, domoic acid and ibotenic acid on mechanical responses of the hindgut isolated from American cockroaches were examined by measuring isotonic contractions with a mechano-electroc transducer. Ibotenic acid exerted an inhibitory effect, and all others had excitatory actions. L-glutamic acid and quisqualic acid produced phasic-tonic contractions, while kainic acid and domoic acid produced phasic contractions only. Verapamil at 5×10^<-6> M abolished spontaneous peristaltic movements of the isolated hindgut and suppressed the agonist-induced contractile responses by 50% (at 10^<-5>-10^<-4> M agonist concentrations). Ibotenic acid at 5×10^<-5> M completely inhibited the peristaltic movements of the hindgut, and picrotoxinin, a chloride-channel blocker, prevented ibotenate from acting. Responses to L-glutamic acid and quisqualic acid were effectively blocked by glutamate dimethyl ester, but the resonses to kainic acid and domoic acid were more susceptible to blockage by 2-amino-4-phosphonobutyric acid, γ-D-glutamylglycine and D-α-aminoadipic acid. These results sults suggest that there may be three distinct types of glutamate receptors on the hindgut muscle of American cockroaches : the quisqualate-activated receptor (type I) is preferentially antagonized by glutamate dimethyl ester, the kainate/domoinate-activated receptor (type II) is more effectively blocked by 2-amino-4-phosphonobutyric acid and γ-D-glutamylglycine than by glutamate dimethyl ester, and the ibotenate-activated receptor (type III) is sensitive to chloride-channel blocker, picrotoxinin.

• 日本応用動物昆虫学会の論文
• 1988-11-25

著者

• Izawa Norihiko

  Life Science Researach Institute Kumiai Chemical Industry Co. Ltd.

• Abe Hiroshi

  Life Science Research Institute, Kumiai Chemical Industry Co., Ltd.

• Fukami Jun-ichi

  Laboratory Of Biology Meiji College Of Pharmacy

• Nakao Tohru

  Life Science Research Institute Kumiai Chemical Industry Co. Litd.

• Abe Hiroshi

  Life Science Research Institute Kumiai Chemical Industry Co. Ltd.

関連論文

• Transformation of Arabidopsis by mutated acetolactate synthase genes from rice and Arabidopsis that confer specific resistance to pyrimidinylcarboxylate-type ALS inhibitors
• Effects of a Plant-Growth Regulator, Prohexadione-Calcium (BX-112), on the Endogenous Levels of Gibberellins in Rice
• Effects of a Plant-Growth Regulator, Prohexadione, on the Biosynthesis of Gibberellins in Cell-Free Systems Derived from Immature Seeds
• Effects of a New Plant Growth Regulator Prohexadione Calcium (BX-112) on Shoot Elongation Caused by Exogenously Applied Gibberellins in Rice (Oryza sativa L.) Seedlings
• Isolation of 2R, 5R-Dihydroxymethyl-3R, 4R-dihydroxypyrrolidine (DMDP) from the Fermentation Broth of Streptomyces sp. KSC-5791
• A Novel Isourazole Herbicide, Fiuthiacet-Methyl, is a Potent Inhibitor of Protoporphyrinogen Oxidase after Isomerization by Glutathione S-Transferase : PROTEINS, ENZYMES AND METABOLISM
• EAG Responses of Parasitoids, Ascogaster reticulatus WATANABE(Hymenoptera : Braconidae), to the Female Sex Pheromone
• Sex Pheromone of the Female Large Cabbage-heart Caterpillar, Crocidolomia binotalis Zeller (Lepidoptera: Pyralidae)
• Artificial Diet for the Large Cabbage-Heart Caterpillar, Crocidolomia binotalis (ZELL.) (Lepidoptera : Pyralidae)
• Peristaltic Movement and Its Suppression by Chlordimeform, Iproniazid and 2-Amino-4-Phosphonobutyric Acid of the Spermiduct in the Cabbage Armyworm, Mamestra brassicae : Lepidoptera : Noctuidae
• Suppressive Effect of Synthetic Quisqualate Analogues on Peristalsis of the Gut of the American Cockroach, Periplaneta americana L. : Orthoptera : Blattidae
• Suppressive Effect of Magnesium Ions on the Peristalsis of the Gut of the American Cockroach, Periplaneta americana L.(Orthoptera : Blattidae)
• THE INHIBITORY EFFECT OF PAPAVERINE ON RESPIRATION-DEPENDENT CONTRACTURE OF GUINEA PIG TAENIA COLI IN HIGH-K MEDIUM. II. INHIBITION OF MITOCHONDRIAL RESPIRATION
• THE INHIBITORY EFFECT OF PAPAVERINE ON RESPIRATION-DEPENDENT CONTRACTURE OF GUINEA PIG TAENIA COLI IN HIGH-K MEDIUM. III. THE DIFFERENTIAL EFFECT OF PAPAVERINE AND ROTENONE ON DT DIAPHORASE
• THE REGULATION OF RESPIRATION OF GUINEA PIG TAENIA COLT IN HIGH-K MEDIUM; THE ROLE OF NICOTINAMIDE-ADENINE DINUCLEOTIDE, ADENOSINE DIPHOSPHATE AND Ca++
• Herbicide sensitivities of mutated enzymes expressed from artificially generated genes of acetolactate synthase
• A novel mutant acetolactate synthase gene from rice cells, which confers resistance to ALS-inhibiting herbicides
• The Effects of L-Glutamic Acid, Glutamate Agonists, Acetylcholine and Several Drugs on Excitatory Post-Synaptic Potentials at the Neuromuscular Junction of the Larval Mealworm, Tenebrio molitor LINNE (Coleoptera : Tenebrionidae)
• Effect of Chlordimeform and Its Analogues on Mandibular Movements of the Cabbage Armyworm, Mamestra brassicae L.(Lepidoptera : Noctuidae)
• Pharmacological Properties of Hindgut Visceral Muscle of the Cockroach, Periplaneta americana L.(Orthoptera:Blattidae) : I.The Effect of Glutamate Agonists, Glutamate Antagonists and Several Ion Channel Blockers
• The Action of Joro Spider Toxin at the Neuromuscular Junctions of the Mealworm, Tenebrio molitor L.(Coleoptera:Tenebrionidae)
• Neuromodulatory Effects of Octopamine Agonists at Neuromuscular Junctions in the Mealworm, Tenebrio molitor L.(Coleoptera:Tenebrionidae)
• Effects of Domoic and Kainic Acids on the Neuromuscular Junction of Mealworm, Tenebrio molitor : Coleoptera : Tenebrionidae
• Preliminary Survay of Effects of Phenols on the Oxidative Phosphorylation in the American Cockroach Muscle Mitochondria
• The Antifeedant Effects of Chlordime-form on the Cabbage Armyworm, Mamestra brassicae L.(Lepidoptera : Noctuidae)
• Two-Rods Method for Simultaneous Measurement of Mandibular and Thoracic Leg Movements of the Cabbage Armyworm, Mamestra brassicae (Lepidoptera : Noctuidae)
• Site of Chlordimeform Action of the Continuous Burst of Mandibular Movements in the cabbage Armyworm, Mamestra brassicae L. (Kepidoptera : Noctuidae)
• Effect of Chlordimeform and Its Analogues on Wandering Behavior of the Cabbage Armyworm, Mamestra brassicae L. (Lepidoptera : Noctuidae)

もっと見る 閉じる

スポンサーリンク