INHIBITORY EFFECT OF BASSIANOLIDE, A CYCLODEPSIPEPTIDE, ON DRUG-INDUCED CONTRACTIONS OF ISOLATED SMOOTH MUSCLE PREPARATIONS
スポンサーリンク
概要
- 論文の詳細を見る
Bassianol1de (BASS) is a cyclodepsipeptide isolated from cultured mycelia of <I>Beauveria bassiana</I> and is pathogenic to insects. In a longitudinal muscle preparation from guinea pig ileum, 10<SUP>-6</SUP> M BASS almost irreversibly inhibited an isotonic contraction induced by acetylcholine (ACH) and made the dose-response curve shift in parallel to the right (pA<SUB>2</SUB>: 7.6). It also inhibited the contractions induced by carbachol, pilocarpine, histamine, 5-hydroxytriptamine (5-HT) and prostaglandin E<SUB>2</SUB>, but did not inhibit the contraction induced by barium or a high concentration (40-60 mM) of potassium (high K). When applied to the guinea pig vas deferens, 10<SUP>-8</SUP>-10<SUP>-7</SUP> M BASS inhibited an isometric contraction induced by norepinephrine (NE) (3×10<SUP>-6</SUP>-10<SUP>-5</SUP> M), phenylephrine (3×10<SUP>-6</SUP>-10<SUP>-5</SUP> M) or ACH (10<SUP>-6</SUP>-10-<SUP>-5</SUP>M). When the contractions of the three agonists exceeded the concentrations mentioned above, BASS failed to exert an inhibitory effect upon any of these agonists. It also inhibited the contraction caused by carbachol and histamine, but did not inhibit that induced by barium or high K. BASS itself failed to cause the contraction or relaxation of both muscle preparations. From these results, it is suggested that BASS inhibits the contraction induced by an agonist which acts upon selective sites of smooth muscle cells, but which does not inhibit a contraction induced by an agonist that has an effect on non-selective sites of cells.
- 社団法人 日本薬理学会の論文
著者
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Kato Kohji
Department Of Mechanical Engineering Tohoku University
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Shimizu Kazumasa
Department Of Medicine Monash Medical Centre
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URAKAWA Norimoto
Department of Veterinary Pharmacology, Faculty of Agriculture, University of Tokyo
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Nakajyo Shinjiro
Laboratory Of Veterinary Pharmacology Department Of Veterinary Medicine Veterinary And Life Science
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Isogai Akira
Department Of Agricultural Chemistry Faculty Of Agriculture The University Of Tokyo
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NAKAJYO Shinjiro
Department of Veterinary Pharmacology, Nippon Veterinary and Zootechnical College
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KOMETANI Atsuko
Department of Veterinary Pharmacology, Nippon Veterinary and Zootechnical College
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KAMIZAKI Junji
Department of Veterinary Pharmacology, Nippon Veterinary and Zootechnical College
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ISOGAI Akira
Department of Agricultural Chemistry, Faculty of Agriculture, University of Tokyo
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URAKAWA Norimoto
Department of Veterinaly Pharmacology, Faculty of Agriculture, University of Tokyo
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SHIMIZU Kazumasa
Department of Veterinary Pharmacology, Nippon Veterinary and Zootechnical College
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KATO Kohji
Department of Veterinary Pharmacology, Nippon Veterinary and Zootechnical College
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NAKAJYO Shinjiro
Department of Veterinary Pharmacology, Nippon Veterinary and Zootechnical Colleg
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Kato Kohji
Department of Chemistry, Faculty of Science and Technology, Sophia University
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