Neuropharmacological effect of methylmercury in mice with special reference to the central cholinergic system.
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概要
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Effect of methylmercury chloride (MMC) on behavior was studied in male ICR-JCL mice. In order to clarify the causal relationship between the potent suppressing action of MMC on the central cholinergic system and toxic manifestations, behavioral changes induced by MMC were compared with those induced by the two reference drugs, hemicholinium-3 (HC-3) and 3'-chloro-4-stilbazole (CS; a potent choline acetyltransferase inhibitor). When administered intraperitoneally, daily in a dose of 5 mg Hg/kg/day, MMC caused a decrease in spontaneous motor activity, rotarod dysfunction, and hypothermia before an abrupt loss in body weight and the appearance of overt signs. These behavioral changes were similar to some extent to those induced by HC-3 or CS. A single intracerebral injection of HC-3 (51 or 100 μg/kg) caused hypothermia and rotarod dysfunction over a period of 40-250 min. A single intraperitoneal administration of CS (100 or 200 mg/kg) induced a decrease in spontaneous motor activity, hypothermia, and rotarod dysfunction over a period of 1-5 hours after injection. These results suggest that the prior toxic behavioral changes caused by MMC may be related to suppression of the cholinergic system.
- 公益社団法人 日本薬理学会の論文
著者
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Kobayashi Haruo
Department Of Veterinary Medicine Faculty Of Agriculture Iwate University
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Kobayashi Haruo
Department Of Electronic Engineering Faculty Of Engineering Gunma University
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TAKENO Kazu
Department of Veterinary Pharmacology, College of Agriculture, University of Osaka Prefecture
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Takeno Kazu
Department Of Pharmacology College Of Agriculture
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Yuyama Akira
Department Of Animal Husbandry Faculty Of Agriculture Tohoku University
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Yanagiya Iwao
Department Of Pharmacology College Of Agriculture
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Matsusaka Naonori
Department Of Veterinary Medicine Faculty Of Agriculture Iwate University
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KOBAYASHI HARUO
Department of Animal Breeding, Faculty of Agriculture, University of Tokyo
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