An Assay of Histamine Applied from the Mucosal Surface of Isolated Intestine

概要

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1) In order to observe the effects of some drugs applied from the intestinal mucosal surface on the intestinal motility, an everted intestine method is described in detail. 2) In this method, the excised and everted intestinal segment was used, and the intestinal movements were recorded as being the same as in the MAGNUS' method. So the results obtained by this method are favorable when compared with the results obtained by MAGNUS' method (drug action on the serosal surface), but this method is unfavorable for observing the intestinal movements for a long time, because it is not able to enclose sufficient oxygen volume into the sac without evoking peristalses. 3) Histamine (more than 5×10^<-7>g/ml), using the everted intestine method, caused delayed, slow contractions and increased the tone of the intestine. The latent period decreased in step with the increase of the dosage of histamine administered. 4) By shaving the mucosal surface of the everted intestine, the histamine action was potentiated and the latent period became very short comparing with the results obtained by using the only, everted intestine. 5) Mechanical distension of the intestinal wall potentiated the action of histamine applied from the mucosal surface.
大阪府立大学の論文
1959-12-31