Effects of Ca2+ blockers on the various types of stimuli-induced acetylcholine release from guinea pig lleum myenteric plexus.
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概要
- 論文の詳細を見る
In the present study, we investigated the effects of various Ca<SUP>2+</SUP> blockers on the release of acetylcholine (ACh) induced by nicotine, electrical field stimulation (EFS) and high-K<SUP>+</SUP>. Cd<SUP>2+</SUP> markedly depressed the ACh release due to these stimuli. Verapamil inhibited the nicotine-induced ACh release remarkably and the EFS or the high-K<SUP>+</SUP>-induced ACh release to a lesser extent. Since the nicotine and the EFS-induced ACh releases were inhibited by procaine, the local anesthetic property of verapamil likely contributes in part to the inhibition. Diltiazem abolished the nicotine-induced ACh release completely but did not affect the EFS-induced release and significantly increased the high-K<SUP>+</SUP>-induced ACh release. These results suggest the absolute requirement for extracellular Ca<SUP>2+</SUP> in the release of ACh induced by nicotine as well as EFS and high-K<SUP>+</SUP>. In addition, these stimuli may open the same Ca<SUP>2+</SUP> channel to evoke ACh release.
- 公益社団法人 日本薬理学会の論文
著者
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Yokoyama Keiji
Department Of Gastroenterology And Medicine Fukuoka University Faculty Of Medicine
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Yagasaki Osamu
Department Of Pharmacology College Of Agriculture
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YOKOYAMA Keiji
Department of Veterinary Pharmacology, College of Agriculture, University of Osaka Prefecture
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