Contribution of external Ca2+ to the modulation by prostaglandin E2 of the release of acetylcholine from the myenteric plexus of guinea pig ileum.
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概要
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The effects of external concentration of [Ca<SUP>2+</SUP>] ([Ca<SUP>2+</SUP>]<SUB>0</SUB>) on the modulation by indomethacin (IND) or prostaglandin E<SUB>2</SUB> (PGE<SUB>2</SUB>) of the evoked release of acetylcholine (ACh) were investigated in the myenteric plexus of guinea pig ileum. An increase in the [Ca<SUP>2+</SUP>]<SUB>0</SUB> from 0.45 to 3.6 mM depressed both the spontaneous and the nicotine-induced release of ACh, while the releases of ACh induced by electrical-field stimulation (EFS) or by high K<SUP>+</SUP> were augmented. IND and PGE<SUB>2</SUB> did not modify the release of ACh induced by EFS and high K<SUP>+</SUP>, at any given [Ca<SUP>2+</SUP>]<SUB>0</SUB> tested. The nicotine-induced release of ACh was significantly inhibited by IND with no relation to [Ca<SUP>2+</SUP>]<SUB>0</SUB>, and these inhibitory effects of IND were prevented by PGE<SUB>2</SUB>. At 0.45 mM [Ca<SUP>2+</SUP>]<SUB>0</SUB>, the extent of the recovery by PGE<SUB>2</SUB> was less potent than those at other [Ca<SUP>2+</SUP>]<SUB>0</SUB>. IND inhibited the spontaneous release of ACh at lower [Ca<SUP>2+</SUP>]<SUB>0</SUB>, and such inhibition was not observed in the presence of PGE<SUB>2</SUB>. Thus, the modulatory actions of PGE<SUB>2</SUB> on the spontaneous and the nicotine-induced release of ACh may depend partially on [Ca<SUP>2+</SUP>]<SUB>0</SUB>.
- 公益社団法人 日本薬理学会の論文
著者
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Takeuchi Tadayoshi
Department Of Veterinary Pharmacology Graduate School Of Agriculture And Life Sciences Osaka Prefect
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Yagasaki Osamu
Department Of Pharmacology College Of Agriculture
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Yagasaki Osamu
Department of Veterinary Pharmacology, Faculty of Agriculture, University of Osaka Prefecture
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SHIMIZU Mitsuru
Department of Hygienic Chemistry, Osaka City Institute of Public Health and Environmental Sciences
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OKUDA Miho
General Research Center, Funai Pharmaceutical Co., Ltd.
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