Characterization of antimuscarinic effect of cimetropium bromide in guinea pig ileum
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概要
- 論文の詳細を見る
Pharmacological characteristics of cimetropium bromide (cimetropium), a muscariniC receptor antagonist, were studied in longitudinal muscle preparations with myenteric plexus of guinea-pig ileum. Cimetropium was shown to have more potent antimuscarinic effect than butylscopolamine in inhibition of contraction of the preparations. Interestingly, when the inhibitory effects of cimetropium were compared in respect of relative potency to atropine between its effects on electrical field stimulation- or nicotine-, and exogenous ACh-induced contraction, it had a more potent effect on the former contraction than that on the latter one. In the superfusion experiments of the preparation which had been preloaded with labelled choline, cimetropium decreased the labelled ACh release induced by electrical field stimulation under the muscarinic autoinhibition blocked-condition. From these findings, two pharmacologically characteristic effects of cimetropium in addition to postsynaptic muscarinic receptor antagonism were suggested : one is a weak effect on muscarinic autoreceptors in comparison to atropine and the other is an inhibitory effect on the ACh release.
著者
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TAKEUCHI Tadayoshi
Department of Veterinary Pharmacology, Graduate School of Agriculture and Life Sciences, Osaka Prefe
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HATA Fumiaki
Department of Veterinary Pharmacology, Graduate School of Agriculture and Life Sciences, Osaka Prefe
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Hata Fumiaki
Department Of Veterinary Pharmacology Graduate School Of Agriculture And Life Sciences Osaka Prefect
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Hata Fumiaki
大阪府立大学 農学生命科学研究科
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SAITOH Noriko
Department of Veterinary Pharmacology, College of Agriculture, Research Institute for Advanced Scien
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Nishio Hideaki
大阪府立大学 農 獣医薬理
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Nishio Hideaki
Departments Of Veterinary Pharmacology College Of Agriculture
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Nishio H
Department Of Veterinary Pharmacology College Of Agriculture Research Institute For Advanced Science
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Takeuchi Tadayoshi
Department Of Veterinary Pharmacology Graduate School Of Agriculture And Life Sciences Osaka Prefect
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Nishio Hideaki
Department Of Veterinary Pharmacology College Of Agriculture Research Institute For Advanced Science
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Saitoh N
Yokohama National Univ. Yokohama
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Saitoh Noriko
Department Of Veterinary Pharmacology College Of Agriculture Research Institute For Advanced Science
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Saitoh Noriko
Department Of Applied Mathematics Faculty Of Engineering National University Of Yokohama
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HATA Fumiaki
Department of Pharmacology I, Osaka University School of Medicine
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