Relationship Between Inhibitory Effect of Endogenous Opioid via Mu-Receptors and Muscarinic Autoinhibition in Acetylcholine Release From Myenteric Plexus of Guinea Pig Ileum
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概要
- 論文の詳細を見る
Relationship between activation of opioid receptors and muscarinic autoinhibition in acetylcholine (ACh) release from the myenteric plexus was studied in longitudinal muscle myenteric plexus (LMMP) preparations of guinea pig ileum. A mu-receptor agonist, [D-Ala2, N-Me-Phe4, Gly5-ol] enkephalin (DAMGO), at a concentration of 1 μM inhibited the ACh release evoked by electrical field stimulation (EFS) at 1 Hz but not at 10 Hz. After the muscarinic autoreceptors were blocked with atropine (1 μM), DAMGO inhibited EFS-evoked ACh release also at 10 Hz. After the autoreceptors were potently activated with muscarine (200 μM), the inhibitory effect of DAMGO at 1 Hz was abolished. A kappa-receptor agonist, U-50, 488, at 1 μM inhibited the EFS-evoked ACh release both at 1 and 10 Hz. U-50, 488 inhibited ACh release regardless of the presence of atropine or muscarine. A delta-agonist, enkephalin [D-PEN2.5] (PDPDE), did not show any significant effect. On the other hand, a selective mu-receptor antagonist, cyprodime, increased ACh release evoked by EFS at 1 Hz, but not at 10 Hz. After the autoreceptors were blocked, cyprodime increased EFS-evoked ACh release also at 10 Hz. The selective kappa-receptor antagonist, nor-binaltorphimine, did not affect ACh release in the absence or presence of atropine. The results suggest that endogenous opioid(s) inhibits ACh release by activating mu-, but not kappa- and delta-receptors in the LMMP of guinea pig ileum and that the inhibitory effect of endogenous opioid(s) in the ACh release is important when muscarinic autoinhibition mechanism does not fully work.
- 社団法人 日本薬理学会の論文
- 1998-08-01
著者
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TAKEUCHI Tadayoshi
Department of Veterinary Pharmacology, Graduate School of Agriculture and Life Sciences, Osaka Prefe
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HATA Fumiaki
Department of Veterinary Pharmacology, Graduate School of Agriculture and Life Sciences, Osaka Prefe
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Hata Fumiaki
Department Of Veterinary Pharmacology Graduate School Of Agriculture And Life Sciences Osaka Prefect
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Hata Fumiaki
大阪府立大学 農学生命科学研究科
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NISHIO Hideaki
Department of Veterinary Pharmacology, Graduate School of Agriculture and Life Science, Osaka Prefec
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NISHIWAKI Hideyuki
Department of Veterinary Pharmacology, College of Agriculture, Research Institute for Advanced Scien
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SAITOH Noriko
Department of Veterinary Pharmacology, College of Agriculture, Research Institute for Advanced Scien
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Nishio Hideaki
大阪府立大学 農 獣医薬理
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Nishio Hideaki
Departments Of Veterinary Pharmacology College Of Agriculture
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Nishio H
Department Of Veterinary Pharmacology College Of Agriculture Research Institute For Advanced Science
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Takeuchi Tadayoshi
Department Of Veterinary Pharmacology Graduate School Of Agriculture And Life Sciences Osaka Prefect
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Nishio Hideaki
Department Of Veterinary Pharmacology College Of Agriculture Research Institute For Advanced Science
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Saitoh N
Yokohama National Univ. Yokohama
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Saitoh Noriko
Department Of Veterinary Pharmacology College Of Agriculture Research Institute For Advanced Science
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Saitoh Noriko
Department Of Applied Mathematics Faculty Of Engineering National University Of Yokohama
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HATA Fumiaki
Department of Pharmacology I, Osaka University School of Medicine
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