Dual effects of clonidine on amylase secretory responses of rat parotid tissue induced by .BETA.- and .ALPHA.1-agonists.
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概要
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The effects of clonidine on the amylase secretory responses of rat parotid tissue were examined in vitro. Clonidine increased amylase secretion induced by the β-adrenergic agonist isoproterenol and decreased that induced by the α<SUB>1</SUB>-adrenergic agonist methoxamine or phenylephrine with propranolol. Clonidine itself had no significant effect on the secretion. Yohimbine prevented the effects of clonidine on the secretions induced by both adrenergic agonists. Clonidine did not have any significant effect on cyclic AMP accumulation in the tissues induced by the β-adrenergic agonist. The parotid tissue after reserpine treatment exhibited supersensitivity to β- and α<SUB>1</SUB>-adrenergic agonists. In reserpine treated tissues, the stimulatory effect of clonidine on β-agonist-induced secretion disappeared, but the inhibitory effect on α<SUB>1</SUB>-agonist-induced secretion remained unchanged. Similar results were obtained after sympathectomy of the gland. These data suggest that the inhibitory effect of clonidine on α<SUB>1</SUB>-agonist-induced secretion is related to a postsynaptic site, whereas its effect on β-agonist-induced secretion is still unknown.
- 公益社団法人 日本薬理学会の論文
著者
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Ishida Hajime
Department Of Anatomy Faculty Of Medicine University Of The Ryukyus
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KONDO Etsuo
Department of Pharmacology, Tokushima University School of Dentistry
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HATA Fumiaki
Department of Pharmacology I, Osaka University School of Medicine
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