CHARACTERISTICS OF [<SUP>3</SUP>H]E-643-BINDING TO ALPHA ADRENOCEPTORS
スポンサーリンク
概要
- 論文の詳細を見る
Radiolabeled E-643, a newly developed antihypertensive compound, bound specifically to a preparation obtained from rat brain with a maximum of 85 f moles of binding sites per mg protein and a dissociation constant of 0.59 nM. Prazosin markedly inhibited the binding, while yohimbine and clonidine were only weak inhibitors. Other characteristics of the binding of [<SUP>3</SUP>H] E-643 to the brain and its specific binding to preparations of peripheral rat organs were also studied. The present findings suggest that [<SUP>3</SUP>H]E-643 is useful for labeling α<SUB>1</SUB>-adrenoceptors.
- 社団法人 日本薬理学会の論文
著者
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Hata Fumiaki
Department Of Veterinary Pharmacology Graduate School Of Agriculture And Life Sciences Osaka Prefect
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Hata Fumiaki
大阪府立大学 農学生命科学研究科
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Ishida Hajime
Department Of Anatomy Faculty Of Medicine University Of The Ryukyus
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Kondo Shigeru
Department Of Life Science Nagoya University
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KONDO Etsuo
Department of Pharmacology, Tokushima University School of Dentistry
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KAGAWA Kimiya
Department of Pharmacology, Tokushima University School of Dentistry
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ISHIDA Hajime
Department of Pharmacology, Tokushima University School of Dentistry
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HATA Fumiaki
Department of Pharmacology, Tokushima University School of Dentistry
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HATA Fumiaki
Department of Pharmacology I, Osaka University School of Medicine
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