ROLE OF α-ADRENERGIC RECEPTORS IN DENERVATION SUPERSENSITIVITY OF RAT VAS DEFERENS
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概要
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Contractile responses of rat vas deferens were studied with particular attention directed to the role of receptors and neuronal control. Marked contraction of the vas deferens was observed with α-adrenergic agonists, depending on their concentrations. This tissue had a low sensitivity to ACh. Four days after denervation, this tissue showed a supersensitivity to α-adrenergic agonists and a high K<SUP>+</SUP> concentration, but not to ACh. The increase in sensitivity to α-agonists resulted in an enhancement of the maximal response and a shift of the concentration response curve to lower concentrations of these reagents. Alterations were seen in the α-adrenergic receptors in the rat vas deferens, assayed by measuring the binding of [<SUP>3</SUP>H]WB4101. The maximal binding sites decreased significantly to 86 from 142 fmoles per mg protein. The affinity of the receptors for α-agonist, determined by measuring the ability of agonists to displace bound [<SUP>3</SUP>H] WB4101, increased significantly, while the affinity to a-antagonists remained unchanged. Studies on [<SUP>3</SUP>H]QNB binding indicated no significant change in muscarinic ACh receptors after denervation. Thus, supersensitivity of the α-adrenergic mechanism mediated by a specific change in affinity of α-receptors occurs after denervation of rat vas deferens. These changes in sensitivity and in receptors are discussed in relation to the characteristics and roles of α-receptors in the rat vas deferens.
- 社団法人 日本薬理学会の論文
著者
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Hata Fumiaki
Department Of Veterinary Pharmacology Graduate School Of Agriculture And Life Sciences Osaka Prefect
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TAKEYASU Kunio
Department of Medical Biochemistry and Neurobiotechnology Center
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Ishida Hajime
Department Of Anatomy Faculty Of Medicine University Of The Ryukyus
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Yoshida Hiroshi
Department Of Biophysics Graduate School Of Science Kyoto University
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Morikawa Yoshio
Department Of Integrated Structural Biosciences Division Of Veterinary Science Graduate School Of Li
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LAI Ron-Tsan
Department of Pharmacology I, Osaka University School of Medicine
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Yoshida Hiroshi
Departmen Of Radiology School Of Medicine Asahikawa Medical University
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MORIKAWA Yoshio
Department of Veterinary Anatomy, College of Agriculture, University of Osaka Prefecture
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HATA Fumiaki
Department of Pharmacology I, Osaka University School of Medicine
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Morikawa Yoshio
Department of Applied Chemistry, Fukui University
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