1H-[1,2,4]Oxadiazolo[4,3-a]quinoxalin-1-one (ODQ) Inhibits Cyclic GMP-PKG Pathway-Independent Nonadrenergic, Noncholinergic Relaxation in Longitudinal Muscle of the Rectum of Wistar-ST Rats
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概要
- 論文の詳細を見る
Participation of the nitric oxide-cyclic GMP pathway in nonadrenergic, noncholinergic(NANC)relaxation induced by electrical field stimulation of longitudinal muscle of the rectum of Wistar-ST rats was studied by using a selective inhibitor of soluble guanylyl cyclase, 1H-[1, 2, 4]oxadiazolo[4, 3-a]quinoxalin-1-one(ODQ).ODQ concentration dependently inhibited the relaxation and at 10μM, maximally inhibited it by 83%.However, results obtained with NG-nitro-L-arginine, L-arginine and exogenously added nitric oxide excluded the participation of nitric oxide in the relaxation.An inhibitor of cyclic GMP-dependent protein kinase(PKG)partially(39%)inhibited the relaxation.ODQ also significantly inhibited the relaxation, which persisted after the PKG inhibitor-treatment, by 85%.The results strongly suggest that ODQ inhibits the NANC relaxation in a cyclic GMP-PKG pathway-independent manner.
- 社団法人 日本薬理学会の論文
- 2000-02-01
著者
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Nakagawa Masashi
Department of Pathology, Osaka City University Graduate School of Medicine
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Nakagawa Masashi
Department Of Pathology Osaka City University Graduate School Of Medicine
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TAKEUCHI Tadayoshi
Department of Veterinary Pharmacology, Graduate School of Agriculture and Life Sciences, Osaka Prefe
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HATA Fumiaki
Department of Veterinary Pharmacology, Graduate School of Agriculture and Life Sciences, Osaka Prefe
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Hata Fumiaki
Department Of Veterinary Pharmacology Graduate School Of Agriculture And Life Sciences Osaka Prefect
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Hata Fumiaki
大阪府立大学 農学生命科学研究科
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OKISHIO Yutaka
Department of Veterinary Pharmacology, Graduate School of Agriculture and Life Sciences, Osaka Prefe
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NISHIO Hideaki
Department of Veterinary Pharmacology, Graduate School of Agriculture and Life Science, Osaka Prefec
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NIIOKA Satomi
Department of Veterinary Pharmacology, College of Agriculture, Research Institute for Advanced Scien
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YAMAJI Michiru
Department of Veterinary Pharmacology, College of Agriculture, Research Institute for Advanced Scien
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Nishio Hideaki
大阪府立大学 農 獣医薬理
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Nishio Hideaki
Departments Of Veterinary Pharmacology College Of Agriculture
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Nishio H
Department Of Veterinary Pharmacology College Of Agriculture Research Institute For Advanced Science
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Okishio Y
Department Of Veterinary Pharmacology Graduate School Of Agriculture And Life Sciences Osaka Prefect
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Yamaji Michiru
Department Of Veterinary Pharmacology College Of Agriculture Research Institute For Advanced Science
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Takeuchi Tadayoshi
Department Of Veterinary Pharmacology Graduate School Of Agriculture And Life Sciences Osaka Prefect
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Nishio Hideaki
Department Of Veterinary Pharmacology College Of Agriculture Research Institute For Advanced Science
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Saitoh N
Yokohama National Univ. Yokohama
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Saitoh Noriko
Department Of Veterinary Pharmacology College Of Agriculture Research Institute For Advanced Science
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Okishio Yutaka
Department Of Veterinary Pharmacology Graduate School Of Agriculture And Life Sciences Osaka Prefect
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Nakagawa Masashi
Department Of Veterinary Pharmacology College Of Agriculture Research Institute For Advanced Science
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Nakagawa Masashi
Department Of Anesthesiology Social Insurance Kinan Hospital
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HATA Fumiaki
Department of Pharmacology I, Osaka University School of Medicine
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