CONFORMATIONAL CHANGES IN ZYMOGEN GRANULES FROM THE PAROTID GLANDS INDUCED BY ATP AND A LOW CONCENTRATION OF CALCIUM
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概要
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In preceding papers (1, 2), we reported that acetylcholine, excess K<SUP>+</SUP> or noradrenaline in the presence of Ca<SUP>2+</SUP> caused secretion of amylase from slices of parotid glands and release of amylase from zymogen granules, consisting mainly of stored amylase. Moreover, ATP and a low concentration of Ca<SUP>2+</SUP> were also important in the process of secretion. Accordingly, there is some secretory process inside the cell which is regulated by Ca<SUP>2+</SUP>.<BR> It has also been reported that the release of catecholamine from chromaffin granules (3-5) and of acetylcholine from synaptic vesicles were caused by ATP (6). Oka et al. (7) also suggested that the release of catecholamine from chromaffin granules is associated with a change in structure of the granules.<BR> In the present work, we investigated the effect of a low concentration of Ca<SUP>2+</SUP> on the structure of zymogen granules to clarify the relation between release of amylase from the granules and their change in structure.
- 社団法人 日本薬理学会の論文
著者
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Hata Fumiaki
Department Of Veterinary Pharmacology Graduate School Of Agriculture And Life Sciences Osaka Prefect
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Ishida Hajime
Department Of Anatomy Faculty Of Medicine University Of The Ryukyus
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Yoshida Hiroshi
Department Of Biophysics Graduate School Of Science Kyoto University
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Miki Naomasa
Department Of Pharmacology I Osaka University School Of Medicine
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Yoshida Hiroshi
Departmen Of Radiology School Of Medicine Asahikawa Medical University
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MIKI Naomasa
Department of Pharmacology, Faculty of Medicine, Osaka University
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ISHIDA Hajime
Department of Pharmacology, Osaka University, Dental School
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HATA Fumiaki
Department of Pharmacology I, Osaka University School of Medicine
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