Inhibitory Effect of Endomorphin-1 and -2 on Acetylcholine Release From Myenteric Plexus of Guinea Pig Ileum
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概要
- 論文の詳細を見る
Endomorphin-1 and -2, putative endogenous ligands for the mu-opioid receptor, inhibited acetylcholine (ACh) release evoked by electrical field stimulation (EFS) at 1 Hz, which partially activates muscarinic autoreceptors, but not at 10 Hz, which fully activates muscarinic autoreceptors, in longitudinal muscle with the myenteric plexus (LMMP) preparations of guinea pig ileum. After blockade of autoinhibition by atropine, the peptides also inhibited EFS-evoked ACh release at 10 Hz. The inhibitory effects on ACh release were abolished by the mu-opioid antagonist cyprodime. These results suggest that endomorphin-1 and -2 inhibit ACh release from LMMP preparations of guinea pig ileum and that the mechanism of the inhibition must have a component in common with muscarinic autoinhibition.
- 社団法人 日本薬理学会の論文
著者
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TAKEUCHI Tadayoshi
Department of Veterinary Pharmacology, Graduate School of Agriculture and Life Sciences, Osaka Prefe
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HATA Fumiaki
Department of Veterinary Pharmacology, Graduate School of Agriculture and Life Sciences, Osaka Prefe
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Hata Fumiaki
Department Of Veterinary Pharmacology Graduate School Of Agriculture And Life Sciences Osaka Prefect
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Hata Fumiaki
大阪府立大学 農学生命科学研究科
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NISHIO Hideaki
Department of Veterinary Pharmacology, Graduate School of Agriculture and Life Science, Osaka Prefec
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SAITOH Noriko
Department of Veterinary Pharmacology, College of Agriculture, Research Institute for Advanced Scien
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NISHIWAKI Hideyuki
Kawanishi Pharma Research Instilute, Nippon Boehringer Ingelheim Co., Ltd., Department of Veterinary
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Nishio Hideaki
大阪府立大学 農 獣医薬理
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Nishio Hideaki
Departments Of Veterinary Pharmacology College Of Agriculture
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Nishio H
Department Of Veterinary Pharmacology College Of Agriculture Research Institute For Advanced Science
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Takeuchi Tadayoshi
Department Of Veterinary Pharmacology Graduate School Of Agriculture And Life Sciences Osaka Prefect
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Nishio Hideaki
Department Of Veterinary Pharmacology College Of Agriculture Research Institute For Advanced Science
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Saitoh N
Yokohama National Univ. Yokohama
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Saitoh Noriko
Department Of Veterinary Pharmacology College Of Agriculture Research Institute For Advanced Science
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Saitoh Noriko
Department Of Applied Mathematics Faculty Of Engineering National University Of Yokohama
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HATA Fumiaki
Department of Pharmacology I, Osaka University School of Medicine
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