Role of PGE2 in Neurotransmission from Pre- to Post-Ganglionic Hypogastric Nerves of Guinea Pigs.
スポンサーリンク
概要
- 論文の詳細を見る
The hypogastric nerve to guinea pig vas deferens was stimulated pre- or post-ganglionically by adjusting the position of the suction electrode. Both stimulations induced a biphasic contraction consisting of a rapid transient phase and a delayed tonic phase. Indomethacin partially inhibited the contraction induced by pre-ganglionic stimulation, but did not inhibit that induced by post-ganglionic stimulation. Prostaglandin (PG) E<SUB>2</SUB> counteracted the inhibitory effect of indomethacin. Mepacrine also inhibited the contraction induced by pre-ganglionic stimulation. Arachidonic acid and PGE<SUB>2</SUB> both reversed the inhibition. The PGE<SUB>2</SUB>-receptor antagonist SC-19220 inhibited the contraction induced by pre-ganglionic, but not post-ganglionic nerve stimulation. These results suggested that endogenous PGE<SUB>2</SUB> is important in neurotransmission in the pelvic ganglion of guinea pigs.
著者
-
Fujita Akikazu
Department Of Anatomy And Molecular Cell Biology Nagoya University Graduate School Of Medicine
-
Takeuchi Tadayoshi
Department Of Veterinary Pharmacology Graduate School Of Agriculture And Life Sciences Osaka Prefect
-
Yagasaki Osamu
Department Of Pharmacology College Of Agriculture
-
YAGASAKI Osamu
Department of Veterinary Pharmacology, College of Agriculture, University of Osaka Prefecture
-
HATA Fumiaki
Department of Pharmacology I, Osaka University School of Medicine
関連論文
- Ascending contraction and descending relaxation in the distal colon of mice lacking interstitial cells of Cajal
- Examination of the role of cholinergic myenteric neurons with the impairment of neural reflexes in the ileum of c-kit mutant mice
- Participation of ATP in Nonadrenergic, Noncholinergic Relaxation of Longitudinal Muscle of Wistar Rat Jejunum
- Role of the Interstitial Cells Distributed in the Myenteric Plexus in Neural Reflexes in the Mouse Ileum
- Essential Role of the Interstitial Cells of Cajal in Nitric Oxide-Mediated Relaxation of Longitudinal Muscle of the Mouse Ileum
- Department of Ca^-Induced Contraction on ATP in α-Toxin-Permeabilized Preparations of Rat Femoral Artery
- Essential Role of ATP Synthesized by Creatine Kinase in Contraction of α-Toxin Permeabilized Preparations of Tonic Type Smooth Muscle
- Localization of Ca^ -Activated K^+ Channel, SK3, in Fibroblast-Like Cells Forming Gap Junctions With Smooth Muscle Cells in the Mouse Small Intestine
- Origin of Ca^ for Carbachol-Induced Contraction in Longitudinal Muscle of the Proximal Colon of Rats
- Mechanism of a Nitric Oxide Donor NOR 1-Induced Relaxation in Longitudinal Muscle of Rat Proximal Colon
- Mediators and Intracellular Mechanisms of NANC Relaxation of Smooth Muscle in the Gastrointestinal Tract
- Possible Role of Potassium Channels in Mu-receptor-Mediated Inhibition and Muscarinic Autoinhibition in Acetylcholine Release From Myenteric Plexus of Guinea Pig Ileum
- 1H-[1,2,4]Oxadiazolo[4,3-a]quinoxalin-1-one (ODQ) Inhibits Cyclic GMP-PKG Pathway-Independent Nonadrenergic, Noncholinergic Relaxation in Longitudinal Muscle of the Rectum of Wistar-ST Rats
- Mediators of Nonadrenergic, Noncholinergic Relaxation in Longitudinal Muscle of the Intestine of ICR Mice
- Decrease in Participation of Nitric Oxide in Nonadrenergic, Noncholinergic Relaxation of Rat Intestine With Age
- Inhibitory Effect of Endomorphin-1 and -2 on Acetylcholine Release From Myenteric Plexus of Guinea Pig Ileum
- Relationship Between Inhibitory Effect of Endogenous Opioid via Mu-Receptors and Muscarinic Autoinhibition in Acetylcholine Release From Myenteric Plexus of Guinea Pig Ileum
- Muscarinic Autoinhibition and Modulatory Role of Protein Kinase C in Acetylcholine Release from the Myenteric Plexus of Guinea Pig Ileum
- Nonadrenergic, Noncholinergic Relaxation in Longitudinal Muscle of Rat Jejunum
- Cooperation of ATP and Norepinephrine in Inducing Contraction in Guinea Pig Vas Deferens Is Not Associated with Change in Intracellular Ca^Level
- Characterization of antimuscarinic effect of cimetropium bromide in guinea pig ileum
- Relationship Between Muscarinic Autoinhibition and the Inhibitory Effect of Morphine on Acetylcholine Release From Myenteric Plexus of Guinea Pig Ileum
- Essential Role of Newly Synthesized ATP for Cyclic GMP-Induced Relaxation in α-Toxin Permeabilized Smooth Muscle of Rat Proximal Colon
- Effect of 1DMe, a Neuropeptide FF Analog, on Acetylcholine Release From Myenteric Plexus of Guinea Pig Ileum
- The Site Where Newly Synthesized ATP Is Necessary for Tension Development in α-Toxin Permeabilized Preparations of Rat Proximal Colon
- PAC1 Receptor-Mediated Relaxation of Longitudianal Muscle of the Mouse Proximal Colon
- EFFECTS OF HYPOXIA, 2,4-DINITROPHENOL AND OUABAIN ON TWITCH POTENTIATION ELICITED FOLLOWING CONDITIONING PULSES IN THE MOUSE PHRENIC NERVE-DIAPHRAGM PREPARATION
- An Assay of Histamine Applied from the Mucosal Surface of Isolated Intestine
- RELEASE OF PROSTAGLANDINS FROM THE PASSIVELY DISTENDED WALL OF GUINEA PIG SMALL INTESTINE
- INVOLVEMENT OF ADRENERGIC AND SEROTONERGIC NERVOUS MECHANISMS IN ALLETHRIN-INDUCED TREMORS IN MICE
- EVIDENCE OF ASCENDING RELEASE OF ACETYLCHOLINE FROM THE LOCALLY DISTENDED GUINEA PIG ILEUM
- DESCENDING RELEASE OF ACETYLCHOLINE FROM THE LOCALLY DISTENDED GUINEA PIG ILEUM
- CHANGES OF TISSUE ACETYLCHOLINE IN THE DISTENDED INTESTINE
- IS056 Identification of Critical Amino Acid Residues in the Extracellular Linker Region Responsible for the Difference in the Unitary Conductance of SUR/Kir6.0 Complex Channels
- PI-05 Quantitative electron microscopy shows uniform incorporation of triglycerides into existing lipid droplets
- WS5-02 Lipid droplet : ER fusion structure in hepatocytes(Histochemistry of Protein Function)
- 細胞膜糖脂質のナノスケール分布解析
- CONFORMATIONAL CHANGES IN ZYMOGEN GRANULES FROM THE PAROTID GLANDS INDUCED BY ATP AND A LOW CONCENTRATION OF CALCIUM
- CHARACTERISTICS OF [3H]E-643-BINDING TO ALPHA ADRENOCEPTORS
- DIRECT INHIBITORY EFFECT OF HEMICHOLINIUM-No. 3 ON ACETYLCHOLINE RELEASE
- SUBCELLULAR DISTRIBUTION OF ASCORBIC ACID IN RAT BRAIN
- EFFECTS OF SYNAPTIC PLASMA MEMBRANES ON RELEASE OF ACETYLCHOLINE FROM SYNAPTIC VESICLES
- EFFECTS OF LOPERAMIDE ON ACETYLCHOLINE AND PROSTAGLANDIN RELEASE FROM ISOLATED GUINEA PIG ILEUM
- INCREASE IN ACh RELEASE FROM THE RAT BRAIN CORTEX SLICES BY 3, 5-CYCLIC ADENOSINE MONOPHOSPHATE
- ROLE OF α-ADRENERGIC RECEPTORS IN DENERVATION SUPERSENSITIVITY OF RAT VAS DEFERENS
- CHANGES IN α-ADRENERGIC RECEPTORS IN RAT BRAIN IN VITRO BY PREINCUBATION WITH α-ADRENERGIC LIGANDS
- A METHOD FOR DIFFERENTIAL MEASUREMENT OF FREE AND BOUND ACETYLCHOLINE IN THE SMALL INTESTINE
- EFFECTS OF Na+ AND OTHER MONOVALENT CATIONS ON Ca-EFFLUX FROM SYNAPTOSOMES
- B06 SODIUM SALICYLATE FACILITATES CALCIUM-DEPENDENT RELEASE OF TRANSMITTER AT MOUSE NEUROMUSCULAR JUNCTIONS
- Role of PGE2 in Neurotransmission from Pre- to Post-Ganglionic Hypogastric Nerves of Guinea Pigs.
- Cooperation of ATP and norepinephrine in inducing contractile responses in guinea pig vas deferens.
- Inhibitory effect of endogenous macromolecule on the Ca++-stimulated acetylcholine release from the crude synaptic vesicles.
- Supersensitivity of amylase secretion from rat parotid tissue - its selective nature for the .BETA.2-adrenergic response.
- Effects of Ca2+ blockers on the various types of stimuli-induced acetylcholine release from guinea pig lleum myenteric plexus.
- The biochemical and ultrastructural examinations in central cholinergic damage of the rat induced by the intraperitoneal administration of AF64A.
- Dual effects of clonidine on amylase secretory responses of rat parotid tissue induced by .BETA.- and .ALPHA.1-agonists.
- Role of Cyclic AMP in Prostaglandin-Induced Modulation of Acetylcholine Release from the Myenteric Plexus of Guinea Pig Ileum.
- Contribution of external Ca2+ to the modulation by prostaglandin E2 of the release of acetylcholine from the myenteric plexus of guinea pig ileum.
- Effects of H-89, an inhibitor of protein kinase A, on the acetylcholine release from myenteric plexus of guinea pig ileum.
- Effect of external Ca2+ on the spontaneous and the various stimuli-induced acetylcholine release from guinea-pig ileum myenteric plexus.
- Forskolin induces supersensitivity of the amylase secretory response of rat parotid tissue.
- Modulation of acetylcholine release from guinea-pig ileum myenteric plexus by arachidonic acid cascade inhibitors.
- Effects of adenylate cyclase inhibitors, phosphodiesterase inhibitors, and dibutyryl cyclic AMP on spontaneous and various stimuli-induced acetylcholine release from guinea pig ileum myenteric plexus.