Relationship Between Muscarinic Autoinhibition and the Inhibitory Effect of Morphine on Acetylcholine Release From Myenteric Plexus of Guinea Pig Ileum
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概要
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The relationship between muscarinic autoinhibition and the inhibitory effect of morphine on acetylcholine (ACh) release was investigated in a longitudinal muscle with myenteric plexus (LMMP) preparation of guinea pig ileum. Morphine (10 μM) inhibited spontaneous and evoked ACh release by electrical field stimulation (EFS) at 1 Hz but not at 10 Hz. Atropine (1 μM) did not affect the resting ACh release, but it significantly increased EFS-evoked release, suggesting activation of muscarinic autoreceptors by ACh released during EFS. Only when the autoinhibition was weakened by atropine, morphine exhibited an inhibitory effect on the EFS-evoked release at 10 Hz. Bethanechol (300 μM) inhibited the EFS-evoked release at 1 Hz but not 10 Hz, suggesting that muscarinic autoreceptors are partially or almost fully activated at 1 or 10 Hz stimulation, respectively. After bethanechol treatment, morphine did not exhibit its inhibitory effect on the EFS-evoked release at 1 Hz. Naloxone (1 μM) increased spontaneous and EFS-evoked ACh release at 1 Hz but not at 10 Hz. Following treatment with atropine, naloxone also increased ACh release at 10-Hz stimulation. These results suggest that morphine and an endogenous opioid inhibit ACh release from LMMP preparations when muscarinic autoinhibition mechanism does not fully work. This inhibitory effect of morphine is discussed in relation to the calcium sensitivity of the preparations in ACh release.
- 社団法人 日本薬理学会の論文
- 1998-08-01
著者
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TAKEUCHI Tadayoshi
Department of Veterinary Pharmacology, Graduate School of Agriculture and Life Sciences, Osaka Prefe
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HATA Fumiaki
Department of Veterinary Pharmacology, Graduate School of Agriculture and Life Sciences, Osaka Prefe
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Hata Fumiaki
Department Of Veterinary Pharmacology Graduate School Of Agriculture And Life Sciences Osaka Prefect
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Hata Fumiaki
大阪府立大学 農学生命科学研究科
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NISHIWAKI Hideyuki
Department of Veterinary Pharmacology, College of Agriculture, Research Institute for Advanced Scien
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SAITOH Noriko
Department of Veterinary Pharmacology, College of Agriculture, Research Institute for Advanced Scien
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Nishio Hideaki
大阪府立大学 農 獣医薬理
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Nishio Hideaki
Departments Of Veterinary Pharmacology College Of Agriculture
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Nishio H
Department Of Veterinary Pharmacology College Of Agriculture Research Institute For Advanced Science
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Takeuchi Tadayoshi
Department Of Veterinary Pharmacology Graduate School Of Agriculture And Life Sciences Osaka Prefect
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Nishio Hideaki
Department Of Veterinary Pharmacology College Of Agriculture Research Institute For Advanced Science
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Saitoh N
Yokohama National Univ. Yokohama
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Saitoh Noriko
Department Of Veterinary Pharmacology College Of Agriculture Research Institute For Advanced Science
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Saitoh Noriko
Department Of Applied Mathematics Faculty Of Engineering National University Of Yokohama
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HATA Fumiaki
Department of Pharmacology I, Osaka University School of Medicine
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NISHIWAKI Hideyuki
Department of Applied Pharmacology, Kyoto College of Pharmacy
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