INVOLVEMENT OF ADRENERGIC AND SEROTONERGIC NERVOUS MECHANISMS IN ALLETHRIN-INDUCED TREMORS IN MICE
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概要
- 論文の詳細を見る
Oral or intravenous administrasion of allethrin, a synthetic derivative of the pirethrin-based insecticides, produces neurotoxic symptoms consisting of mild salivation, hyperexcitability, tremors and convulsions which result in death. Intracerebroventricular injection of allethrin to mouse at about one-nineth the dose of intravenous administration, produced qualitatively identical but less prominent symptoms, indicating that at least some of the symptoms may be originated in the central nervous system. To investigate the mechanism of action of the compound, we studied the ability of agents which alter neurotransmission to prevent or potentiate the effect of convulsive doses of technical grade (15.5% cis, 84.5% trans) allethrin. Intraperitoneal pretreatment with drugs which block noradrenergic receptors or norepinephrine synthesis, such as pentobarbital, chlorpromazine, phentolamine, phenoxybenzamine and reserpine, depressed the tremor induced by allethrin. The inhibitory effect of reserpine was reversed by phenylephrine. Both the serotonergic blocker, methysergide, and the serotonin depletor, p-chlorphenylalanine, potentiated the effect of allethrin. The potentiating effect of methysergide was antagonized by 5-hydroxytryptamine. However, intracere-broventricular administration of methysergide was ineffective in potentiating the effect of allethrin. α_2-and β-adrenoceptor blockers, muscarinic antagonists, GABA mimenergics and morphine had no effect. These results suggest that allethrin produces its neurotoxic responses in mice by acting on the brain and spinal levels. Furthermore, adrenergic excitatory and serotonergic inhibitory mechanisms may be involved in the neural pathway through which the allethrin-inudced tremor is evoked.
- 日本トキシコロジー学会の論文
- 1984-05-25
著者
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NISHIMURA Masakazu
Department of Pathobiological Science, Obihiro University of Agriculture and Veterinary Medicine
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YANAGIYA Iwao
Department of Veterinary Pharmacology, College of Agriculture, University of Osaka Prefecture
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Yanagiya Iwao
Department Of Veterinary Pharmacology College Of Agriculture University Of Osaka Prefecture
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Yanagiya Iwao
Department Of Pharmacology College Of Agriculture
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Yagasaki Osamu
Department Of Veterinary Pharmacology College Of Agriculture University Of Osaka Prefecture
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Yagasaki Osamu
Department Of Pharmacology College Of Agriculture
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OBANA Noriko
Department of Veterinary Pharmacology, College of Agriculture, University of Osaka Prefecture
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Nishimura Masakazu
Department Of Veterinary Pharmacology College Of Agriculture University Of Osaka Prefecture
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Nishimura Masakazu
Department Of Pathobiological Science Obihiro University Of Agriculture And Veterinary Medicine
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Obana Noriko
Department Of Veterinary Pharmacology College Of Agriculture University Of Osaka Prefecture
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