A MECHANISM OF THE THEARUBIGIN FRACTION OF BLACK TEA (CAMELLIA SINENSIS) EXTRACT PROTECTING AGAINST THE EFFECT OF TETANUS TOXIN

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概要

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• The aim of the present study was to elucidate the mechanism of the protective effect of black tea extract's thearubigin fraction against the action of tetanus toxin. The effects of thearubigin fraction extracted from a black tea infusion were examined for neuromuscular blocking action on tetanus toxin in mouse phrenic nerve-diaphragm preparations and on the binding of this toxin to the synaptosomal membrane preparations of rat cerebral cortices. The interaction between tetanus toxin and thearubigin fraction was also investigated. Tetanus toxin (4 μg/ml) abolished indirect twitches in mouse phrenic nerve-dia-phragm preparations within 150 min. Thearubigin fraction mixed with tetanus toxin blocked the inhibitory effect of the toxin. Mixing iodinated toxin with thearubigin fraction inhibited the specific binding of [^125I]tetanus toxin to the synaptosomal membrane preparation. The effects of thearubigin fraction were dose-dependent. The elution profile of [^125I]tetanus toxin on Sephadex G-50 column chromatography was different from that of toxin mixed with thearubigin fraction. These findings indicate that thearubigin fraction protects against the action of tetanus toxin by binding with the toxin.

• 日本トキシコロジー学会の論文
• 2002-12-25

著者

• ISHII Toshiaki

  Department of Molecular Physiology and Biochemistry, Research Institute for Advanced Science and Tec

• Satoh E

  Department Of Pathobiological Science Obihiro University Of Agriculture And Veterinary Medicine

• Ishii Toshiaki

  岐阜大学 大学院連合獣医学研究科病態獣医学連合講座

• Ishii Toshiaki

  Department Of Cardiology Surugadai-nihon University Hospital

• Ishii Toshiaki

  Department Of Pathogenetic Veterinary Science The United Graduate School Of Veterinary Sciences Gifu

• Ishii Toshiaki

  Department Of Pathobiological Science Obihiro University Of Agriculture And Veterinary Medicine

• Ishii Toshiaki

  Dep. Of Basic Veterinary Medicine Obihiro Univ. Of Agriculture And Veterinary Medicine

• NISHIMURA Masakazu

  Department of Pathobiological Science, Obihiro University of Agriculture and Veterinary Medicine

• Shimizu Yoshio

  Gynecologic Oncology Center International University Of Health And Welfare

• Shimizu Yoshio

  Department Of Gynecology Cancer Institute Hospital

• Ishii T

  The Department Of Pulmonary Medicine Yokohama City University Medical Center

• Nishimura M

  Department Of Pathobiological Science Obihiro University Of Agriculture And Veterinary Medicine

• Shimizu Y

  Gynecologic Oncology Center International University Of Health And Welfare

• SATOH Eiki

  Department of Pathobiological Science, Obihiro University of Agriculture and Veterinary Medicine

• SHIMIZU Yoshio

  Cooperative Research Center, Obihiro University of Agriculture and Veterinary Medicine

• SAWAMURA Shin-ichi

  Ito En, Ltd.

• Nishimura Masakazu

  Department Of Pathobiological Science Obihiro University Of Agriculture And Veterinary Medicine

• Sawamura Shin-ichi

  Ito En Ltd.

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