EFFECT OF REPEATED ADMINISTRATIONS OF NEOMYCIN ON THE NEUROMUSCULAR FUNCTIONS AND THE ENHANCEMENT OF D-TUBOCURARINE ACTION IN MICE
スポンサーリンク
概要
- 論文の詳細を見る
Effects of repeated s.c. treatments with 50 μmol (approx. 31 mg)/kg/day of neomycin for 10 or 15 days were examined in mice. There were no significant differences between saline and neomycin treatment groups in the motor coordination assessed by rota-rod test and traction test. On tension recordings, an in vitro addition of d-tubocurarine inhibited the twitch tensions evoked by the nerve stimulations in both cases of saline or neomycin treatment. Neomycin treatments shifted the concentration-response curve between twitch tension and d-tubocurarine to the left, dependently on its injection days. These results suggest that repeated treatments with neomycin enhance the inhibitory effect of d-tubocurarine on the neuromuscular transmission in mice without eliciting motor incoodination and muscle relaxation.
- 日本トキシコロジー学会の論文
- 1995-09-25
著者
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Tsusaki Hideshi
Department Of Toxicology School Of Veterinary Medicine University Of Osaka Prefecture
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Kurebe Masaru
Department Of Toxicology School Of Veterinary Medicine Osaka Prefecture University
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Kurebe Masaru
Department Of Toxicology School Of Veterinary Medicine University Of Osaka Prefecture
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Nishimura Masakazu
Department Of Pathobiological Science Obihiro University Of Agriculture And Veterinary Medicine
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Nishimura Masakazu
Department Of Toxicology School Of Veterinary Medicine University Of Osaka Prefecture
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TSUSAKI Hideshi
Department of Toxicology, School of Veterinary Medicine, University of Osaka Prefecture
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