A SIMPLE METHOD FOR SCREENING ASSESSMENT OF SKIN AND EYE IRRITATION
スポンサーリンク
概要
- 論文の詳細を見る
A stepwise, simple screening test for skin and eye irritations, suitable for industrial chemicals or pesticides which are not required to be examined for their exact potential irritancy levels, was developed. The efficacy of the test was evaluated using 15 chemicals including typical irritants (acetic acid, ammonia, chloroacetic acid, dioxane ethanolamine, formaldehyde, formic acid, hydrogen peroxide, phenol, phosphoric acid, propionic acid, sodium hydroxide, sodium hypochlorite, sulfuric acid, and trichloroacetic acid). Chemicals were chosen so as to represent irritants which act by different mechanisms (i. e., strongly acidic, alkaline, reactive to protein, oxidizing etc.). The method consisted of physicochemical tests and animal tests using rats, mice or guinea pigs, namely, a skin irritation test, an intradermal reaction test and an eye irritation test in a sequential manner such that further tests are not required if a positive result is obtained in earlier steps. Results obtained between two laboratories using this method were very similar. Comparison of our results with the data obtained by the conventional method using rabbits showed fairly good coincidence. The method was shown to be useful in assessing skin and eye irritation of chemicals and causes minimal suffering to animals.
- 日本トキシコロジー学会の論文
- 1994-02-25
著者
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YASUHARA Kazuo
San-Ei Gen F.F.I., Inc.
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Yasuhara Kazuo
San-ei Gen F.f.i. Inc.
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Yasuhara Kazuo
大雄会医科学研究所
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Yasuhara Kazuo
National Institute of Health Sciences
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Nishimura Masao
Department of Cardiology, Ageo Central General Hospital
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TOBE Masuo
Natl. Inst. Hyg. Sci.
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Tobe Masuo
Society Of Japanese Pharmacopeia
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Tobe Masuo
Division Of Toxicology National Institute Of Hygienic Sciences
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Suyama Yuji
Department Of Hygiene Tokyo Dental College
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YAMANAKA Sumie
Department of Hygiene Tokyo Dental College
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Yamanaka Sumie
Department Of Epidemiology And Public Health Tokyo Dental College
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SEKIZAWA JUN
National Institute of Hygienic Sciences
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Sekizawa Jun
National Institute Of Health Sciences
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Sekizawa Jun
Division Of Chem-bio Informatics National Institute Of Health Sciences
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Nishimura M
Department Of Pathobiological Science Obihiro University Of Agriculture And Veterinary Medicine
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Nishimura Masao
Department Of Cardiology Ageo Central General Hospital
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Tobe M
Laboratory Of Signal Transduction Institute For Molecular And Cellular Regulation Gunma University
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Tobo Masayuki
Laboratory Of Signal Transduction Institute For Molecular And Cellular Regulation Gunma University
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Tobe Masuo
Div. Of Toxicol. Biol. Res. Center Natl. Inst. Hygienic Sci.
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