Sphingosylphosphorylcholine Antagonizes Proton-Sensing Ovarian Cancer G-Protein-Coupled Receptor 1 (OGR1)-Mediated Inositol Phosphate Production and cAMP Accumulation
スポンサーリンク
概要
- 論文の詳細を見る
Ovarian cancer G-protein-coupled receptor 1 (OGR1), previously proposed as a receptor for sphingosylphosphorylcholine (SPC), has recently been identified as a proton-sensing or extracellular pH-responsive G-protein-coupled receptor stimulating inositol phosphate production, reflecting the activation of phospholipase C. In the present study, we found that acidic pH stimulated cAMP accumulation, reflecting the activation of adenylyl cyclase, in addition to inositol phosphate production in OGR1-expressing cells. The cAMP response was hardly affected by the inhibition of phospholipase C. SPC inhibited the acidification-induced actions in a pH-dependent manner, while no OGR1-dependent agonistic action of SPC was observed. Thus, the dose-response curves of the proton-induced actions were shifted to the right in the presence of SPC regardless of stereoisoform. The antagonistic property was also observed for psychosine and glucosylsphingosine. In conclusion, OGR1 stimulation may lead to the activation of adenylyl cyclase in addition to phospholipase C in response to extracellular acidification but not to SPC. However, SPC and related lysolipids antagonize the proton-induced and OGR1-mediated actions.
- 社団法人 日本薬理学会の論文
- 2005-10-20
著者
-
Sato Koichi
Department Of Energy Engineering And Science Nagoya University
-
Okajima Fumikazu
韓国
-
Okajima F
Laboratory Of Signal Transduction Institute For Molecular And Cellular Regulation Gunma University
-
Wang Ju-qiang
Laboratory Of Signal Transduction Institute For Molecular And Cellular Regulation Gunma University
-
MOGI CHIHIRO
Laboratory of Signal Transduction, Institute for Molecular and Cellular Regulation, Gunma University
-
TOBE Masuo
Natl. Inst. Hyg. Sci.
-
OKAJIMA Fumikazu
Laboratory of Signal Transduction, Institute for Molecular and Cellular Regulation, Gunma University
-
SATO Koichi
Laboratory of Signal Transduction, Institute for Molecular and Cellular Regulation, Gunma University
-
TOMURA Hideaki
Laboratory of Signal Transduction, Institute for Molecular and Cellular Regulation, Gunma University
-
Mogi Chihiro
Laboratory Of Signal Transduction Institute For Molecular And Cellular Regulation Gunma University
-
Shibuta Kenji
Department Of Clinical Onocology Medical Institute Of Bioregulation Kyushu University
-
Tomura Hideaki
Laboratory Of Signal Transduction Institute For Molecular And Cellular Regulation Gunma University
-
TOBO Masayuki
Laboratory of Signal Transduction, Institute for Molecular and Cellular Regulation, Gunma University
-
DAMIRIN Alatangaole
Laboratory of Signal Transduction, Institute for Molecular and Cellular Regulation, Gunma University
-
KON Junko
Laboratory of Signal Transduction, Institute for Molecular and Cellular Regulation, Gunma University
-
KOMACHI Mayumi
Laboratory of Signal Transduction, Institute for Molecular and Cellular Regulation, Gunma University
-
HASHIMOTO Kinji
Nutrition Research Institute, Otsuka Pharmaceutical Factory, Inc.
-
Kon Junko
Laboratory Of Signal Transduction Institute For Molecular And Cellular Regulation Gunma University
-
Tobe M
Laboratory Of Signal Transduction Institute For Molecular And Cellular Regulation Gunma University
-
Komachi Mayumi
Laboratory Of Signal Transduction Institute For Molecular And Cellular Regulation Gunma University
-
Mogi Chihiro
Laboratory Of Animal Reproduction College Of Animal Science And Technology Nanjing Agricultural Univ
-
Hashimoto Kinji
Nutrition Research Institute Otsuka Pharmaceutical Factory Inc.
-
Tobo Masayuki
Laboratory Of Signal Transduction Institute For Molecular And Cellular Regulation Gunma University
-
Okajima Fumikazu
Laboratory Of Signal Transduction
-
Damirin Alatangaole
Laboratory Of Signal Transduction Institute For Molecular And Cellular Regulation Gunma University
-
Sato Koichi
Laboratory Of Signal Transduction Institute For Molecular And Cellular Regulation Gunma University
関連論文
- Dose-dependent Effects of a Glucocorticoid on Prolactin Production
- CHARACTERIZATION OF A NON-HORMONE PRODUCING PITUITARY CELL LINE (MTT/E) AS A PROGENITOR OF SOMATOTROPE
- S2-4 Function and structure of folliculo-stellte cells in the anterior pituitary gland
- Mode of growth hormone cell differentiation(Endocrinology)(Proceeding of the Seventy-Third Annual Meeting of the Zoological Society of Japan)
- A novel temperature sensitive cell line (Tpit/E and Tpit/F1) established from the anterior pituitary gland of T - antigen transgenic mouse
- Asymmetric Flux Generation and Its Relaxation in Reversed Field Pinch
- B09 CHRONIC TOXICITY STUDY OF p-sec-BUTYLPHENOL IN RATS
- A20 STUDY ON THE DEPRESSED BODY WEIGHT GAIN INDUCED BY 2, 2'-METHYLENE-bis(4-ETHYL-6-tert-BUTYLPHENOL)(MBEBP) IN RAT
- SHORT-TERM TOXICITY STUDY OF 4-DIMETHYLAMINOAZOBENZENE IN MARMOSETS
- SHORT TERM TOXICITY STUDY OF DIMETHYLAMINOAZOBENZENE (DAB) IN MARMOSETS
- TOXICITIES OF MICROENCAPSULATED TRIBROMOMETHANE, DIBROMOCHLOROMETHANE AND BROMODICHLOROMETHANE ADMINISTERED IN THE DIET TO WISTAR RATS FOR ONE MONTH
- SIX-MONTH TOXICITY STUDY OF MITOMYCIN C IN MARMOSETS
- C08 TOXICOLOGICAL SIGNIFICANCES OF RED BLOOD CELL (RBC) COUNT AND DISTRIBUTION OF NUCLEATED CELLS IN BONE MARROW
- Dimethylsphingosine Regulates Intracellular pH and Ca^ in Human Monocytes
- Study on Action Mode of Sphingosine 1-Phosphate in Rat Hepatocytes
- TOXICITY STUDIES OF A SYNTHETIC ANTIOXIDANT, 2,2'-METHYLENEBIS (4-ETHYL-6-TERT-BUTYLPHENOL) IN RATS 1. ACUTE AND SUBCHRONIC TOXICITY
- C07 TOXICITY OF 2-MERCAPTOBENZOTHIAZOLE(MBT) IN MICE
- C06 TOXICOLOGICAL STUDY ON 2-(4-MORPHOLINOTHIO)BENZOTHIAZOLE (2-MTBT) IN MICE
- CHRONIC TOXICITY STUDY OF 2-MERCAPTOIMIDAZOLINE (2-MIZ) IN MICE
- Effect of Plasma Biasing on Suppression of Electrostatic Fluctuation in the Edge Region of STP-3(M) Reversed Field Pinch(Gases, Plasmas and Electric Discharges)
- Contribution of the Electrostatic Fluctuation to the Particle and Energy Fluxes in the Edge Region of STP-3 (M) Reversed Field Pinch Plasma (Gases, Plasmas and Electric Discharges)
- Superthermal Electron Diffusion Processes in a Reversed Field Pinch
- Far-Infrared Laser Interferometry Measurements on the STP-3(M) Reversed-Field Pinch
- New Features of the Reversed-Field Pinch Dynamo
- Coupling of Tearing Modes in Normal RFP Discharge
- Monte Carlo Studies of Transport in a Reversed Field Pinch
- Observation of m=0 Structure with Streak Picture in a Reversed Field Pinch Having Large Magnetic Reynolds Number
- A 3-D Resistive MHD Simulation Analysis of Field Reversal Control in the Reversed Field Pinch
- The Measurement of Soft X-Rays from the STP-3(M) Reversed-Field Pinch Plasma
- Self-Organization and Plasma Dynamo in a Reversed Field Pinch
- Enhancement of Impurity Influx Due to the Dynamo Action in RFP Plasma
- Behavior of the Peripheral Plasma in Reversed Field Pinch
- Mechanism of activation of proximate mutagens in Ames tester strains: The acetyl-CoA dependent enzyme in Salmonella typhimurium TA98 deficient in TA98/1, 8-DNP_6 catalyzed DNA-binding as the cause of mutagenicity
- COMRARISON OF TOXICITY OF p-DICHLOROBENZENE (p-DCB) GIVEN ORALLY AND BY INHALATION
- TOXICITY OF 2-MERCAPTOIMIDAZOLINE (2-MIZ) (2ND REPORT) SUBACUTE TOXICITY IN MICE
- Regional Expression of CXCL12/CXCR4 in Liver and Hepatocellular Carcinoma and Cell-cycle Variation during in vitro Differentiation
- TOXICITY OF ORIENTAL BEZOAR AND ITS COMPONENTS
- L-myc Restriction Fragment Length Polymorphism in Japanese Patients with Esophageal Cancer
- TOXICOLOGICAL EFFECTS OF SOME INHALED CHEMICALS ON THE RESPIRATORY TRACT AND THE LUNGS OF RATS (2nd report)
- TOXICOLOGICAL EFFECTS OF SOME INHALED CHEMICALS ON THE RESPIRATORY TRACT AND THE LUNGS OF RATS (first report)
- TOXICITY OF 2-MERCAPTOIMIDAZOLINE (2-MIZ) III TRANSFER THROUGH THE MATERNAL MILK AND EFFECT OF 2-MIZ TO THE OFFSPRING MICE
- TOXICITY OF 2-MERCAPTOIMIDAZOLINE (2-MIZ) (1ST REPORT) ACUTE TOXICITY AND IMMUNOTOXICITY OF 2-MIZ IN MICE
- Estimation of Acute Inhalation Toxicity (LC_) from Acute Toxicity (LD_) of Other Exposure Routes (Proceedings of the 18th Symposium on Toxicology, and Environmental Health)
- EFFECT OF MITOMYCIN C ON BONE MARROW CELLS IN MICE
- Sphingosylphosphorylcholine Antagonizes Proton-Sensing Ovarian Cancer G-Protein-Coupled Receptor 1 (OGR1)-Mediated Inositol Phosphate Production and cAMP Accumulation
- A SIMPLE METHOD FOR SCREENING ASSESSMENT OF SKIN AND EYE IRRITATION
- N,N-Dimethyl-D-erythro-Sphingosine Inhibits Store-Operated Ca^ Entry in U937 Monocytes
- CHARACTERIZATION OF SIGNALING PATHWAYS THROUGH PROTON-SENSING G-PROTEIN-COUPLED RECEPTORS
- Enhancement of Sphingosine 1-Phosphate-Induced Phospholipase C Activation During G_0-G_1 Transition in Rat Hepatocytes
- Sphingosine 1-Phosphate Stimulates Insulin Secretion in HIT-T 15 Cells and Mouse lslets
- Proinflammatory Cytokines Suppress the Expression Level of Protease-Activated Receptor-2 through the Induction of iNOS in Rat Colon
- EFFECTS OF METYRAPONE ON PLASMA CORTICOSTERONE LEVELS AND INCIDENCE OF CLEFT PALATE IN PREGNANT ddY-Slc MICE FED POLYCHLORINATED TERPHENYLS
- INHALATION TOXICITY STUDY OF FORMALDEHYDE (NASAL CAVITY CANCER OF RATS)
- THE INTERACTION OF POLYCHLORINATED BIPHENYLS AND METHYLMERCURY CHLORIDE IN RATS
- CHRONIC TOXICITY OF MICROENCAPSULATED BROMODICHLOROMETHANE ADMINISTERED IN THE DIET TO WISTAR RATS
- Anti-atherogenic Actions of High-density Lipoprotein through Sphingosine 1-Phosphate Receptors and Scavenger Receptor Class B Type I
- ACUTE AND CHRONIC TOXICITY OF DIISOPROPYLNAPHTHALENE
- The Action Mode of Lysophosphatidylcholine in Human Monocytes
- Untreated Graves' but not Remission Graves' Immunoglobulin G Preparations Increase Intracellular Ca^ in FRTL-5 Thyroid Cells
- B08 CHRONIC TOXICITY STUDIES ON TBM, DBCM AND BDCM IN WISTAR RATS
- OJ-097 Enhancement of High-Density Lipoprotein-induced Anti-Inflammatory Actions in Endothelial Cells by Simvastatin-induced expression of Scavenger Receptor Class B Type I(Atherosclerosis, basic(02)(IHD),Oral Presentation(Japanese),The 72nd Annual Scient
- PE-036 Role of Sphingosine 1-Phosphate Receptors and SR-BI in HDL-Induced Inhibition of Adhesion Molecule Expression in Endothelial Cells(Atherosclerosis, basic-4, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- Inhibition of Sphingosine 1-Phosphate Receptor-Mediated Expression of Adhesion Molecules by High-Density Lipoprotein/Scavenger Receptor-BI/NO Synthase Pathway(Atherosclerosis, Basic 4 (IHD), The 69th Annual Scientific Meeting of the Japanese Circulation S
- Involvement of sphingosine 1-phosphate and its receptors in high-density lipoprotein-induced stimulation of astroglial cell function
- Prostaglandin E2 Inhibits Proteinase-Activated Receptor 2-Signal Transduction through Regulation of Receptor Internalization
- Characterization of Anoikis-Resistant Cells in Mouse Colonic Epithelium
- Phagocytotic Activation of Muscularis Resident Macrophages Inhibits Smooth Muscle Contraction in Rat Ileum
- Enhancement of Sphingosine 1-Phosphate-Induced Phospholipase C Activation During G0-G1 Transition in Rat Hepatocytes