Study on Action Mode of Sphingosine 1-Phosphate in Rat Hepatocytes

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概要

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• Sphingosine-1-phosphate (S1P) acts on a set of G protein-coupled receptors in the plasma membrane and also as a second messenger in certain cell types. There are two possible pathways to mobilize intracellular Ca2+ concentration by S1P. One is through phospholipase C, and the other is through intracellular Ca2+ channels operated by S1P. The Mn2+ quenching method was applied to elucidate the action mode of S1P-induced Ca2+ mobilization in rat hepatocytes. In permeabilized hepatocytes, inositol trisphosphate induced Mn2+ quenching, and it was blocked by heparin. However, S1P did not induce Mn2+ quenching. Results suggest that S1P did not mobilize Ca2+ through intracellular Ca2+ channels.

• 社団法人 日本薬理学会の論文
• 2005-03-20

著者

• Sato Koichi

  Department Of Energy Engineering And Science Nagoya University

• KATADA Toshiaki

  Department of Life Science,Tokyo Institute of Technology

• Okajima Fumikazu

  韓国

• Okajima F

  Laboratory Of Signal Transduction Institute For Molecular And Cellular Regulation Gunma University

• Lee Yun-kyung

  Laboratory Of Pharmacology College Of Pharmacy (bk21 Project) And Longevity Life Science And Technol

• Ui Michio

  The Tokyo Metropolitan Institute Of Medical Sciences

• Lee Eun-hee

  Laboratory Of Pharmacology College Of Pharmacy And Research Institute For Drug Development Pusan Nat

• IM Young-Jin

  Laboratory of Pharmacology, College of Pharmacy and Research Institute for Drug Development, Pusan N

• OKAJIMA Fumikazu

  Laboratory of Signal Transduction, Institute for Molecular and Cellular Regulation, Gunma University

• IM Dong-Soon

  Laboratory of Pharmacology, College of Pharmacy and Research Institute for Drug Development, Pusan N

• SATO Koichi

  Laboratory of Signal Transduction, Institute for Molecular and Cellular Regulation, Gunma University

• TOMURA Hideaki

  Laboratory of Signal Transduction, Institute for Molecular and Cellular Regulation, Gunma University

• Im D‐s

  Laboratory Of Pharmacology College Of Pharmacy (bk21 Project) And Longevity Life Science And Technol

• Im Dong-soon

  Laboratory Of Pharmacology College Of Pharmacy Pusan National University

• Im Young-jin

  Laboratory Of Pharmacology College Of Pharmacy And Research Institute For Drug Development Pusan Nat

• Shibuta Kenji

  Department Of Clinical Onocology Medical Institute Of Bioregulation Kyushu University

• Tomura Hideaki

  Laboratory Of Signal Transduction Institute For Molecular And Cellular Regulation Gunma University

• Katada Toshiaki

  Department Of Life Science Tokyo Institute Of Technology

• Katada Toshiaki

  Department Of Physiological Chemistry Graduate School Of Pharmaceutical Sciences The University Of T

• Okajima Fumikazu

  Laboratory Of Signal Transduction

• Sato Koichi

  Laboratory Of Signal Transduction Institute For Molecular And Cellular Regulation Gunma University

• Katada Toshiaki

  Department of Clinical Laboratory Medicine, Gunma University Graduate School of Medicine

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