REGULATION OF THE ALPHA-ADRENERGIC SYSTEM IN RAT VAS DEFERENS
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概要
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Regulation of the supersensitivity and subsensitivity of the alpha adrenergic (α-Ad) system of rat vas deferens cultured under various experimental conditions was investigated. Muscles cultured for 3 days in normal medium (Eagles MEM) exhibited marked increase in maximal contraction to noradrenaline (NA) and high K<SUP>+</SUP> (154 mM), while muscles cultured with NA (100 μM) were subsensitive to the stimulants. Studies on the binding of <SUP>3</SUP>H-WB4101, an α-Ad antagonist, to the homogenates of normal, supersensitive and subsensitive muscles revealed that the changes in NA-sensitivity were not accompanied by changes in the number or affinity of α-Ad receptors in the muscles. The effect of NA in decreasing NA-sensitivity was depressed by an inhibitor of protein synthesis, puromycin or cycloheximide. These results suggest that NA may be important in regulation of the contraction, at least in part through protein synthesis, without affecting the number or affinity of α-Ad receptors.
- 社団法人 日本薬理学会の論文
著者
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TAKEYASU Kunio
Department of Medical Biochemistry and Neurobiotechnology Center
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Higuchi Hiroshi
Department Of Electrical Engineering Ii Kyoto University
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Uchida Shuji
Department Of Pharmacology I Osaka University School Of Medicine
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Yoshida Hiroshi
Department Of Biophysics Graduate School Of Science Kyoto University
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Matsumoto Kazuo
Department Of Cardiology Saitama Medical School
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Fujita Norihisa
Department Of Biotechnology Faculty Of Science And Engineering Ritsumeikan University
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Yoshida Hiroshi
Departmen Of Radiology School Of Medicine Asahikawa Medical University
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MATSUMOTO Kazuo
Department of Pharmacology I, Osaka University School of Medicine
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HIGUCHI Hiroshi
Department of Pharmacology I, Osaka University School of Medicine
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FUJITA Norihisa
Department of Pharmacology I, Osaka University School of Medicine
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