Effect of calcitonin gene-related peptide on the cyclic AMP level of isolated mouse diaphragm.
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概要
- 論文の詳細を見る
The effect of calcitonin gene-related peptide (CGRP) on the cyclic nucleotide level in isolated mouse diaphragm was investigated. CGRP at concentrations of up to 1 μM caused dose-dependent increases in cyclic AMP levels but had no effect on cyclic GMP levels. At 1 μM, CGRP increased cyclic AMP levels by about 2.7-fold. Moreover, in the presence of phosphodiesterase inhibitor (Ro 20-1724), CGRP still caused even greater dose-dependent increases in cyclic AMP levels. Even in the presence of propranolol, a beta-adrenergic antagonist, CGRP stimulated increased cyclic AMP levels. In addition, specific binding of CGRP was observed in mouse diaphragm. All these results suggest that CGRP increases intracellular cyclic AMP levels via a CGRP receptor but not the betaadrenergic receptor.
- 公益社団法人 日本薬理学会の論文
著者
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Tohyama Masaya
Department Of Anatomy (ii) Osaka University Medical School
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Uchida Shuji
Department Of Pharmacology I Osaka University School Of Medicine
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Yoshida Hiroshi
Departmen Of Radiology School Of Medicine Asahikawa Medical University
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Hashimoto Kazuya
Department Of Cultural Anthropology Kyoto Bunkyo University
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TAKAMI Kenji
Department of Neuroanatomy, Institute of Higher Nervous Activity
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TOHYAMA Masaya
Department of Neuroanatomy, Institute of Higher Nervous Activity
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YOSHIDA Hiroshi
Department of Pharmacology I, Osaka University Medical School
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