Axonal blockade induces the expression of vasoactive intestinal polypeptide and galanin in rat dorsal root ganglion neurons

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概要

• 論文の詳細を見る

• Nerve erowth factor (NGF) undergoes retrograde transport from peripheral target organs, and has been recently reported to regulate the production of some neuropeptides in dorsal root ganglion (DRG) neurons. Therefore, to ascertain whether or not the expression of calcitonin gene-related prptide (CGRP), vasoactive intestinal polypeptide (VIP), and galanin was regulated by the retrograde transport of factors such as NGF, we carried out an immunocytochemical analysis using vinblastine as an axonal transport blocker and a monoclonal antibody to the NGF receptor (NGFR) as a marker of NGF-responsive neurons. The percentage of CGRP-containing DRG neurons (L5) was decreased by sciatic nerve transection or by the application of higher doses of vinblastine (0.3-0.6 mM) to the sciatic nerve. VIP and galanin were expressed in some DRG neurons after the application of a low dose of vinblastine (0.15 mM), which can block axonal now without causing neuronal damage. The expression of these peptides was not affected by dorsal rhizotomy. About 70% of the CGRP-containing neurons also expressed NGFR, while most of the VIP-containing or galanin-containing neurons lacked NGFR. These findings indicate that the depletion of peripheral target-derived neurotrophic factor(s) other than NGF by axonal blockade may induce the gene expression of VIP and galanin.

• 関西鍼灸大学の論文
• 1993-04-01

著者

• UEDA Yoshihiro

  Department of Astronomy, Kyoto University

• SENBA Emiko

  Department of Neuroanatomy, Institute of Higher Nervous Activity, Osaka University Medical School

• Ueda Yoshihiro

  Department Of Physiology Kansai College Of Acupuncture Medicine

• Ueda Yoshihiro

  Department Of Applied Biological Chemistry The University Of Tokyo

• Kashiba Hitoshi

  Department of Physiology, Kansai College of Acupuncture Medicine

• Kawai Yoshinori

  Department of Anatomy (II), Wakayama Medical College

• Thoyama Masaya

  Department of Anatomy (II), Osaka University, Medical School

• Kawai Yoshinori

  Department Of Anatomy (ii) Wakayama Medical College

• Tohyama Masaya

  Department Of Anatomy (ii) Osaka University Medical School

• Kashiba Hitoshi

  Department Of Applied Physiology Osaka University Of Health And Sport Sciences:department Of Physiol

• Senda Emiko

  Department Of Anatomy (ii) Osaka University Medical School:department Of Anatomy (ii) Wakayama Medic

• Senba Emiko

  Department Of Anatomy And Neurobiology Wakayama Medical College

• UEDA YOSHIHIRO

  Department of Physiology, Kansai College of Acupuncture Medicine

• SENBA Emiko

  Department of Anatomy & Neurobiology, Wakayama Medical University

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