Co-localized but target-unrelated expression of vasoactive intestinal polypeptide and galanin in rat dorsal root ganglion neurons after peripheral nerve crush injury

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概要

• 論文の詳細を見る

• Expression of vasoactive intestinal polypeptide (VIP) and galanin in dorsal root ganelion (DRG) neurons is known to be induced by peripheral nerve injury. We investigated (1) whether VIP and galanin were co-expressed by DRG neurons and (2) whether such neurons innervated specified peripheral targets (visceral, cutaneous or muscular). An antibody to the 200 kDa neurofilament subunit (NF200) was used as a marker for large type-A cells in the DRG. VIP and galanin were respectively observed in 22% and 67% of DRG neurons at the L5 spinal level after crushing of the sciatic nerve. Most VIP-containing neurons were small type-B cells (about 90%) and approximately 95% of VIP-containing neurons also showed galanin-like immunoreactivity. Galanin was expressed by both large type-A and small type-B cells. lmmunocytochemistry combined with a retrograde tracer revealed that about 70-80% of the small tvpe-B cells in each sensory division displayed VIP-like immunoreactivity, and that most of the tracer-labeled neurons also expressed galanin. These findings suggest that the expression VIP and/or galanin in response to peripheral nerve crush injury is a property common to visceral, cutaneous and muscular sensory neurons.

• 関西鍼灸大学の論文
• 1993-04-01

著者

• UEDA Yoshihiro

  Department of Astronomy, Kyoto University

• Tohyama Masaya

  Department of Anatomy, Osaka University Medical School

• SENBA Emiko

  Department of Neuroanatomy, Institute of Higher Nervous Activity, Osaka University Medical School

• Ueda Yoshihiro

  Department Of Physiology Kansai College Of Acupuncture Medicine

• Ueda Yoshihiro

  Department Of Applied Biological Chemistry The University Of Tokyo

• Kashiba Hitoshi

  Department of Physiology, Kansai College of Acupuncture Medicine

• Tohyama Masaya

  Department Of Anatomy (ii) Osaka University Medical School

• Kashiba Hitoshi

  Department Of Applied Physiology Osaka University Of Health And Sport Sciences:department Of Physiol

• Senda Emiko

  Department Of Anatomy (ii) Osaka University Medical School:department Of Anatomy (ii) Wakayama Medic

• Senba Emiko

  Department Of Anatomy And Neurobiology Wakayama Medical College

• UEDA YOSHIHIRO

  Department of Physiology, Kansai College of Acupuncture Medicine

• SENBA Emiko

  Department of Anatomy & Neurobiology, Wakayama Medical University

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