Changes of vinculin and extracellular matrix components following blunt trauma to rat skeletal muscle
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概要
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KAMI, K., M. MASUHARA. H. KASHIBA, Y. KAWAI, K. NOGUCHI and E. SENBA. Changes of vinculin and extracellular matrix components following blunt trauma to rat skeletal muscle. Med, Sci. Sports Exerc., Vol. 25, No. 7, pp. 832-840, 1993. The purpose of the present study was to determine changes in the localization of vinculin, Type IV collagen, laminin, and fibronectin during the damage-repair process in the skeletal muscle over several days following acute blunt trauma. A single blunt trauma to the gastrocnemius muscle of the rat was induced by applying 1.57 J of kinetic energy to one leg. By day 2 after trauma, vinculin had disappeared rapidly from the intracellular submembraneous region corresponding to the costamere, whereas Type IV collagen and laminin persisted around the degenerating myofibers (corresponding to the basement membrane). Fibronectin could be observed filling the widened endomysium and in the ruptured myofibers. In the early phase of muscle regeneration (day 5 after trauma), newly synthesized vinculin, Type IV collagen, and laminin formed ring-like structures around the regenerating myotubes. Fibronectin could also be observed filling the widened endomysium around the regenerating myotubes. Further, when small newly formed or solitted myofibers were observed in the areas of regenerating myofibers (day 10 der trauma), vinculin, Type IV collagen, laminin, and fibronectin were localized in specialized regions corresponding to the costamere, basement membrane, and endomysium. These results demonstrated that restoration of the costamere, basement membrane, and endomysium are essential to The maturation of regenerating myofibers after injury.
- 関西鍼灸大学の論文
- 1994-04-01
著者
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KAMI Katsuya
Department of Health Science, Osaka University of Health and Sport Sciences
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MASUHARA Mitsuhiko
Department of Health Science, Osaka University of Health and Sport Sciences
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SENBA Emiko
Department of Neuroanatomy, Institute of Higher Nervous Activity, Osaka University Medical School
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Kami Katsuya
Department Of Applied Physiology Osaka University Of Health And Sport Sciences:department Of Physiol
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Kashiba Hitoshi
Department of Physiology, Kansai College of Acupuncture Medicine
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Masuhara Mitsuhiko
Department Of Applied Physiology Osaka University Of Health And Sport Sciences:department Of Physiol
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Kashiba Hitoshi
Department Of Applied Physiology Osaka University Of Health And Sport Sciences:department Of Physiol
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Senba Emiko
Department Of Anatomy And Neurobiology Wakayama Medical College
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Senba Emiko
Department Of Applied Physiology Osaka University Of Health And Sport Sciences:department Of Physiol
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KAWAI YOSINORI
Department of Applied Physiology, Osaka University of health and Sport Sciences
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NOGUCHI KOICHI
Department of Applied Physiology, Osaka University of health and Sport Sciences
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Noguchi Koichi
Department Of Applied Physiology Osaka University Of Health And Sport Sciences:department Of Physiol
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Noguchi Koichi
Department Of Anatomy And Neuroscience Hyogo College Of Medicine
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Kawai Yosinori
Department Of Applied Physiology Osaka University Of Health And Sport Sciences:department Of Physiol
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SENBA Emiko
Department of Anatomy & Neurobiology, Wakayama Medical University
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