Effects of pantoyl-GABA on GABAA and GABAB receptors in the rat brain.
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概要
- 論文の詳細を見る
The interactions of the "antidementia drug" pantoyl-γ-aminobutyric acid (pantoyl-GABA) with γ-aminobutyric acid (GABA) receptors were investigated by studies on bindings of radiolabelled ligands in rat brain. Pantoyl-GABA inhibited the binding of [<SUP>3</SUP>H]GABA to GABA<SUB>A</SUB> receptors and those of [<SUP>3</SUP>H]baclofen and [<SUP>3</SUP>H]GABA to GABA<SUB>B</SUB> receptors in the rat cerebral cortex. These data suggest that pantoyl-GABA interacts with both types of GABA receptors in the rat brain.
- 公益社団法人 日本薬理学会の論文
著者
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Uchida Shuji
Department Of Pharmacology I Osaka University School Of Medicine
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Nishi Nobuo
Department Of Epidemiology Hiroshima Laboratory Radiation Effects Research Foundation
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Kato Susumu
Department Of Anatomy (1) Jikei University School Of Medicine
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Yoshida Hiroshi
Departmen Of Radiology School Of Medicine Asahikawa Medical University
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MIZUSHIMA Atsushi
Departments of Pharmacology I, Osaka University School of Medicin
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NAKAHIRO Masanobu
Department of Pharmacology I, Osaka University School of Medicine
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FUKUCHI Isao
Safety Research Laboratory, Tanabe-Seiyaku Co., Ltd.
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MOCHIZUKI Daisuke
Division of Pharmacology, Medicinal Research Laboratories, Toyo Jozo Co., Ltd.
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NISHI Nobuo
Department of Pharmacology I, Osaka University School of Medicine
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