Changes in density of muscarinic cholinergic receptor by adrenergic denervation with guanethidine.
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概要
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The effects of chronic adrenergic denervation with guanethidine on muscarinic cholinergic receptors (mAChR) were investigated by binding of L-<SUP>3</SUP>H-quinuclidinyl benzilate (<SUP>3</SUP>H-QNB). Guanethidine treatment decreased the amount of mAChR from 102 to 87 fmoles/mg protein in the heart and from 444 to 388 fmoles/mg protein in the small intestine, but increased it from 223 to 282 fmoles/mg protein in the vas deferens, without changes in its characteristics. These findings suggested that adrenergic innervation has different influences on the mAChR population in different tissues.
著者
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Higuchi Hiroshi
Department Of Electrical Engineering Ii Kyoto University
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Uchida Shuji
Department Of Pharmacology I Osaka University School Of Medicine
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Yoshida Hiroshi
Departmen Of Radiology School Of Medicine Asahikawa Medical University
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MURATA Miho
Department of Degenerative Neurological Diseases, National Institute of Neuroscience, National Center of Neurology and Psychiatry (NCNP)
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MURATA Miho
Department of Pharmacology I, Osaka University School of Medicine
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