Effects of bifemelane hydrochloride (MCI-2016) on acetylcholine release from cortical and hippocampal slices of rats.
スポンサーリンク
概要
- 論文の詳細を見る
Bifemelane hydrocholride (MCI-2016) increased high K<SUP>+</SUP>-evoked acetylcholine (ACh) release from cortical and hippocampal slices of rats. The increasing effect of MCI-2016 was abolished in the absence of Ca ion and by pretreatment of reserpine (2.5 mg/kg, i.p.). These results suggest that monoaminergic neurons may be related to the enhancement of ACh release by MCI-2016. High K<SUP>+</SUP>-evoked ACh release from cortical slices was significantly decreased during aging. The decrease in ACh release was ameliorated by pretreatment of MCI-2016 (30 mg/kg, i.p.).
- 公益社団法人 日本薬理学会の論文
著者
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TOBE Akihiro
Biosciences Laboratory, Research Center, Mitsubishi Chemical Industries Limited
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EGAWA Mitsuo
Biosciences Laboratory, Research Center, Mitsubishi Chemical Industries Limited
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HONDA Sachiko
Biosciences Laboratory, Research Center, Mitsubishi Chemical Industries, Ltd.
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SAITO Ken-Ichi
Biosciences Laboratory, Research Center, Mitsubishi Chemical Industries, Ltd.
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- Effects of bifemelane hydrochloride (MCI-2016) on acetylcholine release from cortical and hippocampal slices of rats.