Effects of bifemelane hydrochloride (MCI-2016) on acetylcholine and norepinephrine release from cortical slices of bilaterally carotid-artery-ligated mongolian gerbils.
スポンサーリンク
概要
- 論文の詳細を見る
Effects of bifemelane hydrochloride (MCI-2016) on acetylcholine (ACh) and norepinephrine (NE) release from cortical slices of bilaterally carotid-arteryligated Mongolian gerbils were examined. ACh and NE release from cortical slices of Mongolian geribils were increased 1 hr after the ligation of bilateral carotid arteries. Pretreatment of MCI-2016 (25 mg/kg, i.p.) attenuated the increase in the release of both neurotransmitters. These effects may participate in the protective effect of MCI-2016 on cerebral ischemia in Mongolian gerbils.
- 公益社団法人 日本薬理学会の論文
著者
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TOBE Akihiro
Biosciences Laboratory, Research Center, Mitsubishi Chemical Industries Limited
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EGAWA Mitsuo
Biosciences Laboratory, Research Center, Mitsubishi Chemical Industries Limited
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HONDA Sachiko
Biosciences Laboratory, Research Center, Mitsubishi Chemical Industries, Ltd.
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SAITO Ken-Ichi
Biosciences Laboratory, Research Center, Mitsubishi Chemical Industries, Ltd.
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TOBE Akihiro
Biosciences Laboratory, Research Center, Mitsubishi Chemical Industries, Ltd.
関連論文
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- Effects of 4-(o-benzylphenoxy)-N-methylbutylamine hydrochloride (MCI-2016) on survival time and brain monoamine levels in bilaterally carotid-artery-ligated gerbils.
- Effects of bifemelane hydrochloride (MCI-2016) on acetylcholine level reduced by scopolamine, hypoxia and ischemia in the rats and Mongolian gerbils.
- Effects of bifemelane hydrochloride (MCI-2016) on acetylcholine and norepinephrine release from cortical slices of bilaterally carotid-artery-ligated mongolian gerbils.
- Effects of bifemelane hydrochloride (MCI-2016) on acetylcholine release from cortical and hippocampal slices of rats.