Extension of Time until Cardiac Arrest after Injection of a Lethal Dose of Pentobarbital in the Hibernating Syrian Hamster(Physiology)
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概要
- 論文の詳細を見る
The aim of the present study was to examine whether entry of peripherally injected drugs into the central nervous system is reduced during hibernation. When a lethal dose of pentobarbital was injected intraperitoneally, the time until cardiac arrest was significantly longer in hibernating hamsters than in active controls. The time difference was not a consequence of low body temperature or diminished circulation, because mimicking these parameters in artificial hypothermia did not prolong the time. In contrast, there was no difference in the time until cardiac arrest after intracerebroventricular injection of the anesthetic. These results indicate that entry of peripherally injected anesthetics into the central nervous system may be suppressed during hibernation.
- 社団法人日本獣医学会の論文
- 2009-03-25
著者
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TAKEWAKI Tadashi
Department of Veterinary Physiology, Gifu University
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SHIMIZU Yasutake
Department of Medical Biochemistry, Ehime University School of Medicine
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Shimizu Yasutake
Laboratory Of Physiology Department Of Basic Veterinary Science The United Graduate School Of Veteri
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Shimizu Yasutake
Department Of Medical Biochemistry Ehime University School Of Medicine
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Takewaki T
Laboratory Of Physiology Department Of Basic Veterinary Science The United Graduate School Of Veteri
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MIYAZAWA Seiji
Department of Basic Veterinary Science, Laboratory of Physiology, The United Graduate School of Vete
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SHIINA Takahiko
Department of Basic Veterinary Science, Laboratory of Physiology, The United Graduate School of Vete
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Miyazawa Seiji
Laboratory Of Physiology Department Of Basic Veterinary Science The United Graduate School Of Veteri
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Shiina T
Laboratory Of Physiology Department Of Basic Veterinary Science The United Graduate School Of Veteri
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TAKEWAKI Tadashi
Department of Pathogenetic Veterinary Science, United Graduate School, Gifu University
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