ASCORBIC ACID, AN ENDOGENOUS FACTOR REQUIRED FOR ACETYLCHOLINE RELEASE FROM THE SYNAPTIC VESICLES
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概要
- 論文の詳細を見る
The ACh-releasing factor, which is required for ACh release in presence of 2 mM ATP, 2 mM Mg and 10<SUP>-5</SUP> M Ca from isolated synaptic vesicles, was purified from the synaptosomal cytoplasm of rat brain by Sephadex G-15, DEAE-Sephadex, Sephadex G-10 and AG50W-2X column chromatographies and identified as ascorbic acid. A low concentration of L-ascorbic acid (5×10<SUP>-6</SUP> M) produced a release of ACh from the vesicles in the presence of ATP, MgCl<SUB>2</SUB> and CaCl<SUB>2</SUB>, as did synaptosomal cytoplasm. This release of ACh induced by L-ascorbic acid was found to be dissociable from formation of lipid peroxide. These findings are discussed in relation to the physiological role of L-ascorbic acid in the brain.
- 社団法人 日本薬理学会の論文
著者
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Kuo Che-hui
Department Of Pharmacology Osaka University Medical School
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Yoshida Hiroshi
Department Of Biophysics Graduate School Of Science Kyoto University
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Yoshida Hiroshi
Departmen Of Radiology School Of Medicine Asahikawa Medical University
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KUO Che-Hui
Department of Pharmacology, Cancer Research Institute, Kanazawa University
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KUO Che-Hui
Department of Pharmacology I, Osaka University School of Medicine
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