Effects of Ca Channel Agonists on 45Ca Uptake Differ Depending on the State of NG108-15 Cells. Effects of Ca Channel Agonists on 45Ca Uptake Differ Depending on the State of NG108-15 Cells.
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概要
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We investigated the effects of various Ca channel agonists (Ca agonist) derived from 1, 4-dihydropyridine on KCl-stimulated <SUP>45</SUP>Ca uptake by differentiated and undifferentiated neuroblastoma × glioma hybrid NG108-15 cells with and without dibutyryl cAMP. Ca agonists Bay K 8644, YC-170 and CGP 28392 enhanced KCl-stimulated <SUP>45</SUP>Ca uptake in differentiated NG108-15 cells, but only slightly in undifferentiated NG108-15 cells. The rank order of the enhancing effects was roughly Bay K 8644 > YC-170 >> CGP 28392. These results suggest that there is some difference between the mechanisms by which these Ca agonists affect KCl-stimulated <SUP>45</SUP>Ca uptake in differentiated and undifferentiated NG108-15 cells, although the nature of that difference is not clear.
- 公益社団法人 日本薬理学会の論文
著者
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Ichida Seiji
Department Of Biological Chemistry School Of Pharmaceutical Sciences Kinki University
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Wada Tetsuyuki
Department Of Biological Chemistry Faculty Of Pharmaceutical Sciences Kinki University
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Ichida Seiji
Department of Biological Chemistry, Faculty of Pharmacy, Kinki University
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Wada Tetsuyuki
Department of Biological Chemistry, Faculty of Pharmacy, Kinki University
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Matsuda Naruhisa
Department of Biological Chemistry, Faculty of Pharmacy, Kinki University
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Nakazaki Satori
Department of Biological Chemistry, Faculty of Pharmacy, Kinki University
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- Effects of Ca Channel Agonists on 45Ca Uptake Differ Depending on the State of NG108-15 Cells. Effects of Ca Channel Agonists on 45Ca Uptake Differ Depending on the State of NG108-15 Cells.
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