INHIBITORY EFFECTS OF ALKYLATED BENCE-JONES PROTEIN, k-TYPE LIGHT CHAIN, FROM URINE OF A PATIENT WITH MACROGLOBULINEMIA ON GASTRIC JUICE SECRETION AND ULCERATION IN RATS

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概要

• 論文の詳細を見る

• Bence-Jones protein (BJP) was isolated from the urine of a patient with macroglobulinemia by salting out with ammonium sulfate, followed by chromatography on DEAE-cellulose column and gel filtration. This native BJP was identified as k-type light chain by immunoelectrophoresis and the native light chain showed almost no activity of inhibiting the gastric ulceration in pylorus-ligated rats. In contrast, reduction of the disulfide bond by 2-mercaptoethanol and alkylation of the thiol by iodoacetate in this native light chain resulted in significant inhibition of the gastric ulceration. The alkylated light chain also showed a significant inhibition of gastric juice secretion in pylorus-ligated rats.

• 公益社団法人日本薬学会の論文

著者

• MIMURA TSUTOMU

  Faculty of Pharmaceutical Sciences, Osaka University

• Mimura T

  Faculty Of Pharmaceutical Sciences Osaka University

• Mimura Tsutomu

  Faculty Of Pharmaceutical Sciences Osaka University

• AONUMA SHIGERU

  Faculty of Pharmaceutical Sciences, Osaka University

• Mimura Tsutomu

  Division Of Bio-medical And Immunological Chemistry Faculty Of Pharmaceutical Sciences Osaka Univers

• TSUJIBO Hiroshi

  Faculty of Pharmaceutical Sciences, Osaka University

• KOHDA ISAO

  Faculty of Pharmaceutical Sciences, Osaka University

• Aonuma Shigeru

  Faculty Of Pharmaceutical Sciences Osaka University

• Kohda Isao

  Faculty Of Pharmaceutical Sciences Osaka University

• Mimura T

  Division Of Bio-medical And Immunological Chemistry Faculty Of Pharmaceutical Sciences Osaka Univers

• TERADA TAICHIRO

  Faculty of Pharmaceutical Sciences, Osaka University

• Terada Taichiro

  Faculty Of Pharmaceutical Sciences Osaka University

• EGAWA HIROSHI

  Faculty of Pharmaceutical Sciences, Osaka University

• Mimura T

  Division Of Bio-medical And Immunological Chemistry Faculty Of Pharmaceutical Sciences Osaka Univers

• Egawa Hiroshi

  Faculty Of Pharmaceutical Sciences Osaka University

• Tsujibo Hiroshi

  Faculty Of Pharmaceutical Sciences Osaka University

• Aonuma Shigeru

  Faculty of Pharmaceutical Science, Kinki University

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