偏光顕微鏡による結晶性医薬品の研究(第5報)「日局10」収載抗生物質のPolarizing Microscopy

概要

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By using the improved immersion method and the key refractive indices, about which the authors have already reported, polarizing microscopy has been practised for antibiotic drugs listed mainly in the JPX. As many as 17 drugs in 32 were classified into the group A, from which 2 key refractive indices were measured on the natural position of their thin plate or scale shaped crystals at the immersion process. Seven drugs were classified into the group B, from which one key refractive index was measured from the parallel direction to the elongated position of long prisms or needles showing parallel extinction. While, another 7 drugs did not show double refraction and they were classified into the group D, the cases of isometric or amorphous solids. As they showed irregular shapes, they were determined as amorphous solids, from which an unique refractive index was observed in each substance. It was found that the polarizing microscopy would be applicable for the identification or analysis of such antibiotic drugs. The figure of correlation between refractive indices and birefringence (n_2-n_1) was also conveniently utilized.
社団法人日本薬学会の論文
1984-08-25