薬剤の非同等性に関する研究(第9報)インドメタシンの結晶多形と直腸吸収
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概要
- 論文の詳細を見る
Absorption of indomethacin from the rabbit rectum was examined in comparison with the suppositories containing indomethacin polymorphs (α- or γ-form). Rectal suppositories were made with Witepsol H_<12>. Plasma levels of α-form indomethacin was higher than that of γ-form. The commercial product (Inteban suppository) made with polyethylene glycol (PEG) base was also examined. Plasma level of Inteban was similar to that of α-form. The relationship between the thermodynamic activities of indomethacin polymorphs and their rectal absorption was discussed.
- 公益社団法人日本薬学会の論文
- 1979-08-25
著者
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山本 智子
神戸女子薬科大学
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浅田 昌三
神戸女子薬科大学
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黒田 耕司
神戸大学医学部附属病院薬剤部
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梅田 常雄
Hospital pharmacy, Kobe University School of Medicine
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黒田 耕司
Hospital Pharmacy Kobe University School Of Medicine
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浅田 昌三
Kobe Women's College Of Pharmacy
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梅田 常雄
Hospital Pharmacy Kobe University School Of Medicine
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